Primary hepatic solitary fibrous tumor with histologically benign and malignant areas

Abstract Extrapleural solitary fibrous tumor (SFT) is an uncommon mesenchymal neoplasm, presenting most commonly in the intrathoracic sites but which has been reported at numerous extrathoracic locations. The majority of intra-thoracic SFTs are benign, but 10%-15% behave aggressively. We report a ca...

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Bibliographic Details
Published in:Hepatobiliary & pancreatic diseases international 2015-12, Vol.14 (6), p.665-668
Main Authors: Silvanto, Anna, Karanjia, Nariman D, Bagwan, Izhar N
Format: Article
Language:English
Subjects:
Aged
Biomarkers, Tumor - analysis
Biopsy
Endocrinology & Metabolism
Gastroenterology and Hepatology
Hepatectomy
Humans
Immunohistochemistry
Incidental Findings
Liver Neoplasms - chemistry
Liver Neoplasms - pathology
Liver Neoplasms - surgery
liver surgery
liver tumors
Male
malignant (non-HCC)
Mitosis
Necrosis
Neoplasms, Complex and Mixed - chemistry
Neoplasms, Complex and Mixed - pathology
Neoplasms, Complex and Mixed - surgery
pathological changes
Solitary Fibrous Tumors - chemistry
Solitary Fibrous Tumors - pathology
Solitary Fibrous Tumors - surgery
Tomography, X-Ray Computed
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Summary:Abstract Extrapleural solitary fibrous tumor (SFT) is an uncommon mesenchymal neoplasm, presenting most commonly in the intrathoracic sites but which has been reported at numerous extrathoracic locations. The majority of intra-thoracic SFTs are benign, but 10%-15% behave aggressively. We report a case of primary hepatic SFT with histologically benign and malignant areas. A 65-year-old man underwent an abdominal CT scan following a cerebrovascular accident, which demonstrated a sharply demarcated large liver mass with a heterogenous enhancing area and occupying most of the left lobe of the liver. Histological examination following a hemihepatectomy showed an SFT with morphological patterns ranging from benign to malignant areas, including pleomorphism, increased cellularity, herringbone pattern, necrosis and a raised mitotic count. On review of the literature, only an occasional case report with malignant areas in a hepatic SFT was identified. This case highlights that SFT should be included in the differential diagnosis of a hepatic spindle cell lesion, and that on rare occasions, malignant areas can occur in this already uncommon neoplasm.
ISSN:1499-3872
DOI:10.1016/S1499-3872(15)60365-4