Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats

BACKGROUND: Post-hepatectomy liver failure as a result of insufficient liver remnant is a feared complication in liver surgery.Efforts have been made to find new strategies to support liver regeneration. The aim of this study was to investigate the effects of terlipressin versus splenectomy on posto...

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Bibliographic Details
Published in:Hepatobiliary & pancreatic diseases international 2017-10, Vol.16 (5), p.506-511
Main Authors: Ulmer, Tom Florian, Weiland, Anne, Lurje, Georg, Klink, Christian, Andert, Anne, Alizai, Hamid, Heidenhain, Christoph, Neumann, Ulf
Format: Article
Language:English
Subjects:
Animals
Body Weight
failure
terlipressin
splenectomy
hepatectomy
Hepatectomy
Ki-67 Antigen - analysis
liver
liver failure
Liver Regeneration
Lypressin - analogs & derivatives
Lypressin - therapeutic use
Male
Portal Pressure
Rats
Rats, Wistar
regeneration
liver
Splenectomy
Terlipressin
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Summary:BACKGROUND: Post-hepatectomy liver failure as a result of insufficient liver remnant is a feared complication in liver surgery.Efforts have been made to find new strategies to support liver regeneration. The aim of this study was to investigate the effects of terlipressin versus splenectomy on postoperative liver function and liver regeneration in rats undergoing 70% partial hepatectomy.METHODS: Seventy-two male Wistar rats were randomly assigned into three groups (n=24 in each group): 70% partial hepatectomy as control (PHC), 70% partial hepatectomy with splenectomy (PHS) or 70% partial hepatectomy with a micropump for terlipressin administration (PHT). Eight rats in each group were sacrificed on postoperative day (POD) 1,3 and 7. To assess liver regeneration, immunohistochemical analysis of liver tissue using bromodeoxyuridine (BrdU) and Ki-67 labeling was performed.
ISSN:1499-3872
DOI:10.1016/S1499-3872(17)60036-5