Apolipoprotein A5 gene polymorphisms are associated with non-alcoholic fatty liver disease

Several studies have reported that apolipoprotein A5 (APOA5) is involved in the development of non-alcoholic fatty liver disease (NAFLD). However, no research has been performed regarding the association between APOA5 polymorphisms and the risk of NAFLD. This study aimed to explore the association b...

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Bibliographic Details
Published in:Hepatobiliary & pancreatic diseases international 2018-06, Vol.17 (3), p.214-219
Main Authors: Xu, Yue, Lu, Lin-Lin, Liu, Shou-Sheng, Du, Shui-Xian, Zhu, Hui-Ling, Dong, Quan-Jiang, Xin, Yong-Ning
Format: Article
Language:English
Subjects:
Adult
Alkaline Phosphatase - blood
Apolipoprotein A-V - genetics
Apolipoprotein A5
Asian Continental Ancestry Group - genetics
Biomarkers - blood
Blood Glucose - metabolism
Case-Control Studies
China - epidemiology
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Heterozygote
Homozygote
Humans
Lipoproteins, HDL - blood
Male
Middle Aged
Non-alcoholic fatty liver disease
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - diagnosis
Non-alcoholic Fatty Liver Disease - ethnology
Non-alcoholic Fatty Liver Disease - genetics
Phenotype
Polymorphism, Single Nucleotide
Risk Factors
Single nucleotide polymorphisms
Triglycerides - blood
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Summary:Several studies have reported that apolipoprotein A5 (APOA5) is involved in the development of non-alcoholic fatty liver disease (NAFLD). However, no research has been performed regarding the association between APOA5 polymorphisms and the risk of NAFLD. This study aimed to explore the association between APOA5 gene polymorphisms and NAFLD in a Chinese Han population. Genotypes of the SNPs (rs10750097, rs1263173, rs17120035, rs3135507 and rs662799) of APOA5 in 232 NAFLD patients and 188 healthy controls were determined using polymerase chain reaction (PCR) analysis. Clinical characteristics were measured using biochemical methods. The five single nucleotide polymorphisms (SNPs) (rs10750097, rs1263173, rs17120035, rs3135507 and rs662799) of APOA5 showed no significant association with NAFLD (P > 0.05). The rs10750097 with G allele showed a higher serum level of alkaline phosphatase (ALP) compared with C allele in overall series and NAFLD patients (P 
ISSN:1499-3872
DOI:10.1016/j.hbpd.2018.04.004