Prognostic value of postoperative complication for early recurrence after curative resection of hepatocellular carcinoma

Postoperative complications may adversely affect oncological outcomes. The aim of this study was to evaluate the impact of postoperative complications on early-phase recurrence after curative resection for hepatocellular carcinoma (HCC). We included 145 HCC patients who underwent initial and curativ...

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Bibliographic Details
Published in:Hepatobiliary & pancreatic diseases international 2018-08, Vol.17 (4), p.323-329
Main Authors: Amisaki, Masataka, Saito, Hiroaki, Tokuyasu, Naruo, Sakamoto, Teruhisa, Honjo, Soichiro, Fujiwara, Yoshiyuki
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Hepatocellular - secondary
Carcinoma, Hepatocellular - surgery
Complications
Female
Hepatectomy - adverse effects
Hepatocellular carcinoma
Humans
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Male
Middle Aged
Neoplasm metastasis
Neoplasm Recurrence, Local
Operative Time
Postoperative Complications - etiology
Progression-Free Survival
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
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Summary:Postoperative complications may adversely affect oncological outcomes. The aim of this study was to evaluate the impact of postoperative complications on early-phase recurrence after curative resection for hepatocellular carcinoma (HCC). We included 145 HCC patients who underwent initial and curative resection between January 2004 and December 2013. Postoperative complications of grade III or higher based on Clavien–Dindo classification were defined as clinically relevant postoperative complications. Recurrence within two years after hepatectomy was defined as early-phase recurrence. Thirty-eight patients (26%) developed postoperative complications. The only predictive factor for postoperative complication was longer operative duration (P = 0.037). The disease-specific survival rate of patients with complication was lower than that of patients without complications (P = 0.015). Early-phase recurrence was observed in 20/38 (53%) patients who suffered postoperative complications and 36/107 (34%) patients with no complications, which was statistically significant (P = 0.039). Multivariate analysis identified four factors contributing to early-phase recurrence: high serum AFP level (P = 0.042), multiple tumors (P 
ISSN:1499-3872
DOI:10.1016/j.hbpd.2018.03.016