Liver stiffness as a predictor of hepatocellular carcinoma behavior in patients with hepatitis C related liver cirrhosis

Risk stratification and prognostication of hepatocellular carcinoma (HCC) help to improve patient outcome. Herein we investigated the role of liver stiffness measurement (LSM) in the prediction of HCC behavior. Totally 121 naïve patients with HCC were included. HCC radiological evaluation and stagin...

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Bibliographic Details
Published in:Hepatobiliary & pancreatic diseases international 2020-02, Vol.19 (1), p.22-28
Main Authors: Lashen, Sameh A, Elshafei, Mohamed M, Hablass, Fahmy H, Alsayed, Eman A, Hassan, Asmaa A
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - pathology
Elasticity Imaging Techniques
Female
Fibrosis
Hepatitis C
Hepatitis C, Chronic - complications
Hepatocellular carcinoma
Humans
Liver cirrhosis
Liver Cirrhosis - complications
Liver Neoplasms - etiology
Liver Neoplasms - pathology
Male
Middle Aged
Neoplasm Recurrence, Local
Point shear wave
ROC Curve
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Summary:Risk stratification and prognostication of hepatocellular carcinoma (HCC) help to improve patient outcome. Herein we investigated the role of liver stiffness measurement (LSM) in the prediction of HCC behavior. Totally 121 naïve patients with HCC were included. HCC radiological evaluation and staging were done. LSM was measured using virtual touch quantification. Patients were divided into early to intermediate HCC (BCLC-0, A and B) and late HCC (BCLCC and D). HCC was treated according to the BCLC stage. HCC recurrence-free interval was estimated. The mean LSM inside the tumor was significantly lower than the peri-tumoral area and the cirrhotic non-cancerous liver parts (P 
ISSN:1499-3872
DOI:10.1016/j.hbpd.2019.11.004