In-vivo behavior of tin-radiopharmaceuticals

R817.4%O613.44; Tin is an essential ingredient of most technetium-99m radiopharmaceuticals but its in-vivo distribution and long-term fate are not well understood. This work describes distribution in mice of several tin-117m labeled compounds. The results indicate that stannic-HEDTMP appears to be t...

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Bibliographic Details
Published in:核技术(英文版) 2003, Vol.14 (2), p.127-130
Main Authors: HE Jia-heng, LUO Shun-Zhong, WANG Guan-quan, YANG Yu-qing, PU Man-Fei, LIU Guo-Ping
Format: Article
Language:English
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Summary:R817.4%O613.44; Tin is an essential ingredient of most technetium-99m radiopharmaceuticals but its in-vivo distribution and long-term fate are not well understood. This work describes distribution in mice of several tin-117m labeled compounds. The results indicate that stannic-HEDTMP appears to be the best overall bone localizing agent with very low blood, muscle, kidney, or liver uptake, and its binding to bone is higher than that of tin-117m-DTPA, which make it potentially useful as an agent for skeletal scintigraphy and radiotherapy of bone tumors.
ISSN:1001-8042