A primary study on biological behavior of aluminum using ^26Al-AMS

Aluminum is concerned as a possible cause of many diseases.To investigate the long-term A1 biokinetics and bioavailability in various kinds of Al-contained medicine and food,an accelerator mass spectrometry（AMS）based on the HI-13 tandem has been established for biological analysis with ^26A1（T1/2 =...

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Bibliographic Details
Published in:Nuclear science and techniques 2016-06, Vol.27 (3), p.25-30, Article 53
Main Authors: Qin, Song-Mei, Wang, Xiang-Gao, Lan, Xiao-Xi, Gu, Yun-Ting, Dong, Ke-Jun, He, Ming, Jiang, Shan
Format: Article
Language:English
Subjects:
AMS
Energy
Hadrons
Heavy Ions
Nuclear Energy
Nuclear Physics
制备过程
加速器质谱
生物分析
生物利用度
生物动力学
生物学特性
铝
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Summary:Aluminum is concerned as a possible cause of many diseases.To investigate the long-term A1 biokinetics and bioavailability in various kinds of Al-contained medicine and food,an accelerator mass spectrometry（AMS）based on the HI-13 tandem has been established for biological analysis with ^26A1（T1/2 = 716,000 years） as the tracer.In this paper,the animal tracing,sample preparation procedure and ^26A1-AMS measurement are presented.The sample preparation procedure has been simplified.A high sensitivity of 5×10^-15 for ^26A1/^27A1 has been achieved.Two phases were found before and after a break time（tb）for the ^26A1 retained in blood and brain,with tb≈8 and12 h after the ^26Al tracer injection,respectively.
ISSN:1001-8042
2210-3147
DOI:10.1007/s41365-016-0065-y