Quantum dots enhanced Cerenkov luminescence imaging

Cerenkov luminescence imaging (CLI) has been widely investigated for biological imaging. However, the luminescence generated from Cerenkov effect is relatively weak and has poor penetration ability in biological tissues. These limitations consequently hindered the clinical translation of CLI. In thi...

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Bibliographic Details
Published in:Nuclear science and techniques 2019-05, Vol.30 (5), p.9-13, Article 71
Main Authors: Geng, Chang-Ran, Ai, Yao, Tang, Xiao-Bin, Shu, Di-Yun, Gong, Chun-Hui, Du, Ming-Hua, Ji, Fa-Quan
Format: Article
Language:English
Subjects:
Energy
Hadrons
Heavy Ions
Nuclear Energy
Nuclear Physics
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Summary:Cerenkov luminescence imaging (CLI) has been widely investigated for biological imaging. However, the luminescence generated from Cerenkov effect is relatively weak and has poor penetration ability in biological tissues. These limitations consequently hindered the clinical translation of CLI. In this study, we proposed an in vitro experimental study for the demonstration of quantum dots (QDs) configurations affected by the improvement of the signal intensity of CLI. Results revealed that the optimal concentrations were 0.1 mg/mL and 0.25 mg/mL for the studied CdSe/ZnS QDs with fluorescence emission peaks of 580 nm and 660 nm, respectively. The detected optical signal intensity with long-wavelength emission QDs were stronger than those with short-wavelength emission QDs. This study illustrates an experiment to study the effects of concentrations and fluorescence emission peaks of QDs on an enhanced optical signal for the external detection of CLI.
ISSN:1001-8042
2210-3147
DOI:10.1007/s41365-019-0599-x