The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families

We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome we...

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Bibliographic Details
Published in:Chinese science bulletin 2000-10, Vol.45 (19), p.1792-1795
Main Authors: Zhao, Jinying, Wang, Heng, Xiong, Momiao, Huang, Wei, Zuo, Jin, Chen, Zhu, Qiang, Boqin, Sun, Qi, Li, Yuxiu, Liu, Qiuying, Du, Weinan, Chen, Jialun, Ding, Wei, Yuan, Wentao, Zhao, Yang, Xu, Hongyan, Jin, Li, Fang, Fude
Format: Article
Language:English
Subjects:
Chromosomes
Diabetes mellitus (non-insulin dependent)
Fluorescent dyes
Fluorescent indicators
Genetic markers
Genomes
Genotyping
Heterogeneity
Localization
Microsatellites
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Summary:We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1, 12, 18, 20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.
ISSN:1001-6538
2095-9273
1861-9541
2095-9281
DOI:10.1007/BF02886269