A possible mode of the specifi-crecognition of nucleic acids by proteins

Q7; Seven sets of protein target sites, which occur in several gene promoters, have been analyzed. The results suggest that there is a possible mode of specific recognition of double-helical nucleic acids by proteins. This recognition mode is related to a special topological property of double-helic...

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Bibliographic Details
Published in:科学通报(英文版) 2001, Vol.46 (11), p.930-934
Main Authors: LI Xuqing, LIU Ciquan
Format: Article
Language:English
Online Access:Get full text
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Summary:Q7; Seven sets of protein target sites, which occur in several gene promoters, have been analyzed. The results suggest that there is a possible mode of specific recognition of double-helical nucleic acids by proteins. This recognition mode is related to a special topological property of double-helical DNA, which is termed base spatial pattern (BSP) of DNA segment. BSP is the spatial topological property determined only by the spatial arrangement of the bases on double-helical DNA segment.
ISSN:1001-6538
DOI:10.1007/BF02900469