Viewpoints on the proinflammation state of leukemia

Proinflammation represents a pathophysiological state on the early stage of a number of diseases, especially the infectious and immunological ones. In recent years, proinflammation has attracted much attention, and the term “proinflammation factors” appears frequently in the literature. While invest...

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Bibliographic Details
Published in:Science bulletin (Beijing) 2003-11, Vol.48 (22), p.2519-2522
Main Authors: Wu, Kefu, Ma, Xiaotong
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Immunology
Interleukin 18
Leukemia
Matrix metalloproteinase
Matrix metalloproteinases
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Summary:Proinflammation represents a pathophysiological state on the early stage of a number of diseases, especially the infectious and immunological ones. In recent years, proinflammation has attracted much attention, and the term “proinflammation factors” appears frequently in the literature. While investigating leukemia and leukemic cells from the angle of “proinflammation state”, we got some intriguing findings, e.g. we detected the significantly elevated expression of proinflammation factor IL-18 in patients with acute myeloid leukemia (AML), which could up-regulate matrix metalloproteinases (MMP) and specific tissue inhibitors (TIMPs). The increased MMP may play a role in the aggressiveness of myeloid leukemic cells, and be associated with a poor prognosis. This phenomenon reflects an ignored aspect of leukemia. Investigations from the angle of “proinflammation state” have broaden the fields of tumor and leukemia study.
ISSN:2095-9273
1001-6538
2095-9281
DOI:10.1360/03wc0339