Identification of Cytochrome P450 (CYP) genes in Zhikong scallop (Chlamys farreri)

Cytochrome P450 ( CYP ) superfamily is one of the membership largest and function most diverse protein superfamily recogniozed among living beings. Members of this superfamily were further assigned to different families and subfamilies based on their amino acid similarities. According to their phylo...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Ocean University of China 2013-03, Vol.12 (1), p.97-102
Main Authors: Guo, Huihui, Bao, Zhenmin, Du, Huixia, Zhang, Lingling, Wang, Shi, Sun, Luyang, Mou, Xiaoyu, Hu, Xiaoli
Format: Article
Language:English
Subjects:
Amino acids
Bivalvia
Chlamys farreri
Cytochrome
Earth and Environmental Science
Earth Sciences
Marine
Meteorology
Mitochondria
Mollusks
Oceanography
Phylogenetics
Proteins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cytochrome P450 ( CYP ) superfamily is one of the membership largest and function most diverse protein superfamily recogniozed among living beings. Members of this superfamily were further assigned to different families and subfamilies based on their amino acid similarities. According to their phylogenetic relationships, the CYP genes which likely diverged from common ancestor gene and may share common functions were grouped into one clan. Widely distributing scallops are a group of the most conspicuous bivalve; however the studies on their CYP is acarce. In this study, we searched the genome and expressed sequence tags of Zhikong scallop ( Chlamys farreri ) for CYP genes. In total, 88 non-redundant CYP were identified, which were homed in 13 CYP s gene families. Phylogenetic analysis divided these genes into 4 CYP clans. As in deuterostomes, Clan 2 was the largest, which contained 33 genes belonging to CYP 1, CYP 2, CYP 17 and CYP 356 families. Clan 3 contgained 19 genes belonging to CYP 3, CYP 5 and CYP 30 families. Clan 4 contained 23 genes, all belonging to CYP 4 family. The mitochondrial CYP clan contained 9 genes belonging to CYP 10 and CYP 24 families. In comparison, protostomes ( C. farreri, D. pluex, D. melanogaster ) contained more CYP genes than deuterostomes ( S. purpuratus and vertebrates) in Clan 2 but less genes in Clan 3 and Clan 4. Our findings will aid to deciphering CYP function and evolution in scallops and bivalves.
ISSN:1672-5182
1993-5021
1672-5174
DOI:10.1007/s11802-013-1967-5