Inhibition of Breast Cancer Resistance Protein (BCRP) by Ko143 Can Affect Pharmacokinetics of Enrofloxacin in Exopalaemon carinicauda

Adenosine triphosphate-binding cassette transporter breast cancer resistance protein (BCRP) exists highly in the apical membranes of epithelia, and is involved in drug availability. Ko143 is a typical inhibitor of BCRP in rodents. The synthetic antibacterial agent enrofloxacin (ENRO) is a fluoroquin...

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Bibliographic Details
Published in:Journal of Ocean University of China 2020-10, Vol.19 (5), p.1116-1124
Main Authors: Zhai, Qianqian, Xu, Yang, Li, Cuiping, Feng, Yanyan, Cui, Yanting, Ma, Li, Li, Jian
Format: Article
Language:English
Subjects:
Abundance
Adenosine triphosphate
Antibiotics
Antiinfectives and antibacterials
ATP
Breast cancer
Cancer
Chemical kinetics
Drug interaction
Drug interactions
Drugs
Earth and Environmental Science
Earth Sciences
Enrofloxacin
Epithelium
Exopalaemon carinicauda
Half-life
Hepatopancreas
Intestine
Intestines
Medical sciences
Membranes
Meteorology
Nucleotide sequence
Oceanography
Oral administration
PCR
Pharmacokinetics
Pharmacology
Polymerase chain reaction
Proteins
Reverse transcription
Shellfish
Substrates
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Summary:Adenosine triphosphate-binding cassette transporter breast cancer resistance protein (BCRP) exists highly in the apical membranes of epithelia, and is involved in drug availability. Ko143 is a typical inhibitor of BCRP in rodents. The synthetic antibacterial agent enrofloxacin (ENRO) is a fluoroquinolone employed as veterinary and aquatic medicine, and also a substrate for BCRP. BCRP gene highly expressed in the hepatopancreas and intestine of Exopalaemon carinicauda as was determined with real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR) method. The effects of Ko143 on the abundance of BCRP mRNA and ENRO pharmacokinetics in E. carinicauda were studied. The mRNA abundance of BCRP decreased significantly in hepatopancreas and intestine ( P
ISSN:1672-5182
1993-5021
1672-5174
DOI:10.1007/s11802-020-4312-9