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Antibiotic usage in Chinese children: a point prevalence survey

Background Children as a population have high antimicrobial prescribing rates which may lead to high resistance of bacteria according to data from some single-center surveys of antibiotic prescribing rates in China. The acquirement of baseline data of antibiotic prescribing is the basis of developin...

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Published in:World journal of pediatrics : WJP 2018-08, Vol.14 (4), p.335-343
Main Authors: Zhang, Jiao-Sheng, Liu, Gang, Zhang, Wen-Shuang, Shi, Hai-Yan, Lu, Gen, Zhao, Chang-An, Li, Chang-Chong, Li, Yan-Qi, Shao, Ya-Nan, Tian, Dai-Yin, Ding, Ming-Jie, Li, Chun-Yan, Luo, Li-Juan, Dong, Xiao-Yan, Jin, Ping, Wang, Ping, Zhu, Chun-Mei, Wang, Chuan-Qing, Zheng, Yue-Jie, Deng, Ji-Kui, Sharland, Mike, Hsia, Ying-Fen, Shen, Kun-Ling, Yang, Yong-Hong
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cited_by cdi_FETCH-LOGICAL-c376t-a7ee8ce7b0b6e182274dc20c255da1d15dd3c6e9a71d66ba8cc3bcc3789fb4af3
cites cdi_FETCH-LOGICAL-c376t-a7ee8ce7b0b6e182274dc20c255da1d15dd3c6e9a71d66ba8cc3bcc3789fb4af3
container_end_page 343
container_issue 4
container_start_page 335
container_title World journal of pediatrics : WJP
container_volume 14
creator Zhang, Jiao-Sheng
Liu, Gang
Zhang, Wen-Shuang
Shi, Hai-Yan
Lu, Gen
Zhao, Chang-An
Li, Chang-Chong
Li, Yan-Qi
Shao, Ya-Nan
Tian, Dai-Yin
Ding, Ming-Jie
Li, Chun-Yan
Luo, Li-Juan
Dong, Xiao-Yan
Jin, Ping
Wang, Ping
Zhu, Chun-Mei
Wang, Chuan-Qing
Zheng, Yue-Jie
Deng, Ji-Kui
Sharland, Mike
Hsia, Ying-Fen
Shen, Kun-Ling
Yang, Yong-Hong
description Background Children as a population have high antimicrobial prescribing rates which may lead to high resistance of bacteria according to data from some single-center surveys of antibiotic prescribing rates in China. The acquirement of baseline data of antibiotic prescribing is the basis of developing intervention strategies on inappropriate antimicrobial prescriptions. Few studies show clearly the pattern and detailed information on classes of antibiotics and distribution of indications of antibiotic prescriptions in children in China. This study aims to assess the antibiotic prescribing patterns among children and neonates hospitalized in 18 hospitals in China. Methods A 24-hour point prevalence survey on antimicrobial prescribing was conducted in hospitalized neonates and children in China from December 1st, 2016 to February 28th, 2017. Information on the antibiotic use of patients under 18 years of age who were administered one or more on-going antibiotics in the selected wards over a 24-hour period was collected. These data were submitted to the GARPEC (Global Antimicrobial Resistance, Prescribing and Efficacy in Children and Neonates) web-based application ( https://pidrg-database.sgul.ac.uk/redcap/ ). For statistical analysis, Microsoft Excel 2007 and SPSS 22.0 were used. Results The antibiotic data were collected in 35 wards in 18 hospitals from 9 provinces. In total, 67.76% (975/1439) of the patients ( n  = 1439) were given at least one antibiotic, including 58.1% (173/298) of neonates ( n  = 298) and 70.3% (802/1141) of children ( n  = 1141). In neonates, the three most frequently prescribed antibiotics were third-generation cephalosporins (41.7%), penicillins plus enzyme inhibitor (23.8%), and carbapenems (11.2%). In children, the three most frequently prescribed antibiotics were third-generation cephalosporins (35.5%), macrolides (23.2%), and penicillins plus enzyme inhibitors (15.9%). The most common indication for antibiotics was proven or probable bacterial lower respiratory tract infection (30.9% in neonates and 66.6% in children). Conclusions Antibiotics are commonly prescribed in the Chinese children population. It is likely that the third-generation cephalosporins and macrolides are currently overused in Chinese children. Efforts must be made to ensure safe and appropriate antibiotic prescribing to reduce and prevent the future development of antibiotic resistance.
doi_str_mv 10.1007/s12519-018-0176-0
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The acquirement of baseline data of antibiotic prescribing is the basis of developing intervention strategies on inappropriate antimicrobial prescriptions. Few studies show clearly the pattern and detailed information on classes of antibiotics and distribution of indications of antibiotic prescriptions in children in China. This study aims to assess the antibiotic prescribing patterns among children and neonates hospitalized in 18 hospitals in China. Methods A 24-hour point prevalence survey on antimicrobial prescribing was conducted in hospitalized neonates and children in China from December 1st, 2016 to February 28th, 2017. Information on the antibiotic use of patients under 18 years of age who were administered one or more on-going antibiotics in the selected wards over a 24-hour period was collected. These data were submitted to the GARPEC (Global Antimicrobial Resistance, Prescribing and Efficacy in Children and Neonates) web-based application ( https://pidrg-database.sgul.ac.uk/redcap/ ). For statistical analysis, Microsoft Excel 2007 and SPSS 22.0 were used. Results The antibiotic data were collected in 35 wards in 18 hospitals from 9 provinces. In total, 67.76% (975/1439) of the patients ( n  = 1439) were given at least one antibiotic, including 58.1% (173/298) of neonates ( n  = 298) and 70.3% (802/1141) of children ( n  = 1141). In neonates, the three most frequently prescribed antibiotics were third-generation cephalosporins (41.7%), penicillins plus enzyme inhibitor (23.8%), and carbapenems (11.2%). In children, the three most frequently prescribed antibiotics were third-generation cephalosporins (35.5%), macrolides (23.2%), and penicillins plus enzyme inhibitors (15.9%). The most common indication for antibiotics was proven or probable bacterial lower respiratory tract infection (30.9% in neonates and 66.6% in children). Conclusions Antibiotics are commonly prescribed in the Chinese children population. It is likely that the third-generation cephalosporins and macrolides are currently overused in Chinese children. Efforts must be made to ensure safe and appropriate antibiotic prescribing to reduce and prevent the future development of antibiotic resistance.</description><identifier>ISSN: 1708-8569</identifier><identifier>EISSN: 1867-0687</identifier><identifier>DOI: 10.1007/s12519-018-0176-0</identifier><language>eng</language><publisher>Hangzhou: Childrens Hospital, Zhejiang University School of Medicine</publisher><subject>Critical Care Medicine ; Imaging ; Intensive ; Maternal and Child Health ; Medicine ; Medicine &amp; Public Health ; Original Article ; Pediatric Surgery ; Pediatrics ; Radiology ; Surgery</subject><ispartof>World journal of pediatrics : WJP, 2018-08, Vol.14 (4), p.335-343</ispartof><rights>Children's Hospital, Zhejiang University School of Medicine 2018</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-a7ee8ce7b0b6e182274dc20c255da1d15dd3c6e9a71d66ba8cc3bcc3789fb4af3</citedby><cites>FETCH-LOGICAL-c376t-a7ee8ce7b0b6e182274dc20c255da1d15dd3c6e9a71d66ba8cc3bcc3789fb4af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/ssekzz/ssekzz.jpg</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Zhang, Jiao-Sheng</creatorcontrib><creatorcontrib>Liu, Gang</creatorcontrib><creatorcontrib>Zhang, Wen-Shuang</creatorcontrib><creatorcontrib>Shi, Hai-Yan</creatorcontrib><creatorcontrib>Lu, Gen</creatorcontrib><creatorcontrib>Zhao, Chang-An</creatorcontrib><creatorcontrib>Li, Chang-Chong</creatorcontrib><creatorcontrib>Li, Yan-Qi</creatorcontrib><creatorcontrib>Shao, Ya-Nan</creatorcontrib><creatorcontrib>Tian, Dai-Yin</creatorcontrib><creatorcontrib>Ding, Ming-Jie</creatorcontrib><creatorcontrib>Li, Chun-Yan</creatorcontrib><creatorcontrib>Luo, Li-Juan</creatorcontrib><creatorcontrib>Dong, Xiao-Yan</creatorcontrib><creatorcontrib>Jin, Ping</creatorcontrib><creatorcontrib>Wang, Ping</creatorcontrib><creatorcontrib>Zhu, Chun-Mei</creatorcontrib><creatorcontrib>Wang, Chuan-Qing</creatorcontrib><creatorcontrib>Zheng, Yue-Jie</creatorcontrib><creatorcontrib>Deng, Ji-Kui</creatorcontrib><creatorcontrib>Sharland, Mike</creatorcontrib><creatorcontrib>Hsia, Ying-Fen</creatorcontrib><creatorcontrib>Shen, Kun-Ling</creatorcontrib><creatorcontrib>Yang, Yong-Hong</creatorcontrib><title>Antibiotic usage in Chinese children: a point prevalence survey</title><title>World journal of pediatrics : WJP</title><addtitle>World J Pediatr</addtitle><description>Background Children as a population have high antimicrobial prescribing rates which may lead to high resistance of bacteria according to data from some single-center surveys of antibiotic prescribing rates in China. The acquirement of baseline data of antibiotic prescribing is the basis of developing intervention strategies on inappropriate antimicrobial prescriptions. Few studies show clearly the pattern and detailed information on classes of antibiotics and distribution of indications of antibiotic prescriptions in children in China. This study aims to assess the antibiotic prescribing patterns among children and neonates hospitalized in 18 hospitals in China. Methods A 24-hour point prevalence survey on antimicrobial prescribing was conducted in hospitalized neonates and children in China from December 1st, 2016 to February 28th, 2017. Information on the antibiotic use of patients under 18 years of age who were administered one or more on-going antibiotics in the selected wards over a 24-hour period was collected. These data were submitted to the GARPEC (Global Antimicrobial Resistance, Prescribing and Efficacy in Children and Neonates) web-based application ( https://pidrg-database.sgul.ac.uk/redcap/ ). For statistical analysis, Microsoft Excel 2007 and SPSS 22.0 were used. Results The antibiotic data were collected in 35 wards in 18 hospitals from 9 provinces. In total, 67.76% (975/1439) of the patients ( n  = 1439) were given at least one antibiotic, including 58.1% (173/298) of neonates ( n  = 298) and 70.3% (802/1141) of children ( n  = 1141). In neonates, the three most frequently prescribed antibiotics were third-generation cephalosporins (41.7%), penicillins plus enzyme inhibitor (23.8%), and carbapenems (11.2%). In children, the three most frequently prescribed antibiotics were third-generation cephalosporins (35.5%), macrolides (23.2%), and penicillins plus enzyme inhibitors (15.9%). The most common indication for antibiotics was proven or probable bacterial lower respiratory tract infection (30.9% in neonates and 66.6% in children). Conclusions Antibiotics are commonly prescribed in the Chinese children population. It is likely that the third-generation cephalosporins and macrolides are currently overused in Chinese children. Efforts must be made to ensure safe and appropriate antibiotic prescribing to reduce and prevent the future development of antibiotic resistance.</description><subject>Critical Care Medicine</subject><subject>Imaging</subject><subject>Intensive</subject><subject>Maternal and Child Health</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Original Article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Radiology</subject><subject>Surgery</subject><issn>1708-8569</issn><issn>1867-0687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LAzEQxYMoWKsfwFtunlYn2W6S9SKl-A8KXvQcsslsm1qzJdlW2k9vygqePDxmDu_3hnmEXDO4ZQDyLjFesboAprKkKOCEjJgSsgCh5GneJahCVaI-JxcprQAEZwJG5GEaet_4rveWbpNZIPWBzpY-YEJql37tIoZ7auim86Gnm4g7s8ZgkaZt3OH-kpy1Zp3w6neOycfT4_vspZi_Pb_OpvPCllL0hZGIyqJsoBHIFOdy4iwHy6vKGeZY5VxpBdZGMidEY5S1ZZMlVd02E9OWY3Iz5H6b0Jqw0KtuG0O-qFPCz8OB589hAlBlJxucNnYpRWz1JvovE_eagT52pYeudCb0sSsNmeEDk7I3LDD-xf8P_QDqzWz3</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Zhang, Jiao-Sheng</creator><creator>Liu, Gang</creator><creator>Zhang, Wen-Shuang</creator><creator>Shi, Hai-Yan</creator><creator>Lu, Gen</creator><creator>Zhao, Chang-An</creator><creator>Li, Chang-Chong</creator><creator>Li, Yan-Qi</creator><creator>Shao, Ya-Nan</creator><creator>Tian, Dai-Yin</creator><creator>Ding, Ming-Jie</creator><creator>Li, Chun-Yan</creator><creator>Luo, Li-Juan</creator><creator>Dong, Xiao-Yan</creator><creator>Jin, Ping</creator><creator>Wang, Ping</creator><creator>Zhu, Chun-Mei</creator><creator>Wang, Chuan-Qing</creator><creator>Zheng, Yue-Jie</creator><creator>Deng, Ji-Kui</creator><creator>Sharland, Mike</creator><creator>Hsia, Ying-Fen</creator><creator>Shen, Kun-Ling</creator><creator>Yang, Yong-Hong</creator><general>Childrens Hospital, Zhejiang University School of Medicine</general><general>Department of Infectious diseases,Shenzhen Children's Hospital,Shenzhen,China%Department of Infectious diseases,Beijing Children's Hospital Affiliated to Capital Medical University,Beijing,China%Department of Respiratory Medicine,Tianjin Children's Hospital,Tianjin,China%Department of Pharmacology,Shandong Provincial Qianfoshan Hospital,Shandong University,Jinan,China%Department of Respiratory Medicine,Guangzhou Women and Children's Medical Center,Guangzhou,China%Emergency Department,Guangdong Maternal and Child Health Care Hospital,Guangzhou,China%Department of Pediatric Respiratory Medicine,The Second Affiliated Hospital &amp; Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China%Department of Respiratory Medicine,Xi'an Children's Hospital,Xi'an,China%Department of Respiratory Medicine,Children's Hospital,Zhejiang University School of Medicine,Hangzhou,China%Department of Respiratory Medicine,Children's Hospital of Chongqing Medical University,Chongqing,China%Department of Respiratory Medicine,Jinan Children's Hospital,Jinan,China%Department of Respiratory Medicine,The First Hospital of Jilin University,Changchun,China%Department of Infectious diseases,Shanghai Children's Medical Center,Shanghai Jiaotong University School of Medicine,Shanghai,China%Department of Respiratory Medicine,Shanghai Children's Hospital,Shanghai,China%Pediatric Intensive Care Unit,Bao'an Maternity and Child Health Hospital,Shenzhen,China%Neonatal Department,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing,China%Department of Respiratory Medicine,Children's Hospital Attached to The Capital Institute of Pediatrics,Beijing,China%Infection-control Department,Fudan University Pediatric Hospital,Shanghai,China%Department of Respiratory Medicine,Shenzhen Children's Hospital,Shenzhen,China%Pediatric Infectious Diseases Research Group,St George's,University of London,London,UK%Department of Respiratory Medicine,Beijing Children's Hospital Affiliated to Capital Medical University,Beijing,China%Beijing Pediatric Research Institute,Beijing Children's Hospital Affiliated to Capital Medical University,56 Nanlishi Road,Beijing,China</general><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20180801</creationdate><title>Antibiotic usage in Chinese children: a point prevalence survey</title><author>Zhang, Jiao-Sheng ; 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The acquirement of baseline data of antibiotic prescribing is the basis of developing intervention strategies on inappropriate antimicrobial prescriptions. Few studies show clearly the pattern and detailed information on classes of antibiotics and distribution of indications of antibiotic prescriptions in children in China. This study aims to assess the antibiotic prescribing patterns among children and neonates hospitalized in 18 hospitals in China. Methods A 24-hour point prevalence survey on antimicrobial prescribing was conducted in hospitalized neonates and children in China from December 1st, 2016 to February 28th, 2017. Information on the antibiotic use of patients under 18 years of age who were administered one or more on-going antibiotics in the selected wards over a 24-hour period was collected. These data were submitted to the GARPEC (Global Antimicrobial Resistance, Prescribing and Efficacy in Children and Neonates) web-based application ( https://pidrg-database.sgul.ac.uk/redcap/ ). For statistical analysis, Microsoft Excel 2007 and SPSS 22.0 were used. Results The antibiotic data were collected in 35 wards in 18 hospitals from 9 provinces. In total, 67.76% (975/1439) of the patients ( n  = 1439) were given at least one antibiotic, including 58.1% (173/298) of neonates ( n  = 298) and 70.3% (802/1141) of children ( n  = 1141). In neonates, the three most frequently prescribed antibiotics were third-generation cephalosporins (41.7%), penicillins plus enzyme inhibitor (23.8%), and carbapenems (11.2%). In children, the three most frequently prescribed antibiotics were third-generation cephalosporins (35.5%), macrolides (23.2%), and penicillins plus enzyme inhibitors (15.9%). The most common indication for antibiotics was proven or probable bacterial lower respiratory tract infection (30.9% in neonates and 66.6% in children). Conclusions Antibiotics are commonly prescribed in the Chinese children population. It is likely that the third-generation cephalosporins and macrolides are currently overused in Chinese children. Efforts must be made to ensure safe and appropriate antibiotic prescribing to reduce and prevent the future development of antibiotic resistance.</abstract><cop>Hangzhou</cop><pub>Childrens Hospital, Zhejiang University School of Medicine</pub><doi>10.1007/s12519-018-0176-0</doi><tpages>9</tpages></addata></record>
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subjects Critical Care Medicine
Imaging
Intensive
Maternal and Child Health
Medicine
Medicine & Public Health
Original Article
Pediatric Surgery
Pediatrics
Radiology
Surgery
title Antibiotic usage in Chinese children: a point prevalence survey
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