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Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial
Background Constipation is a common problem in children with spastic cerebral palsy (sCP) with a prevalence that reaches 75%. We hypothesized that treating constipation in those children will improve their health and shorten time spent in daily care. Our aim was to evaluate the efficacy and safety o...
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| Published in: | World journal of pediatrics : WJP 2021-02, Vol.17 (1), p.92-98 |
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| container_title | World journal of pediatrics : WJP |
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| creator | Hassanein, Sahar M. A. Deifallah, Shaymaa M. Bastawy, Hend A. |
| description | Background
Constipation is a common problem in children with spastic cerebral palsy (sCP) with a prevalence that reaches 75%. We hypothesized that treating constipation in those children will improve their health and shorten time spent in daily care. Our aim was to evaluate the efficacy and safety of oral magnesium sulfate for treating chronic constipation in children with sCP.
Methods
A prospective, double-blinded randomized control trial was carried out involving 100 children aged 2–12 years with sCP (level III–V of the Gross Motor Functional Classification system) and chronic constipation. They were followed up in the Pediatric neurology clinic, Children’s hospital, Ain Shams University, May 2017- January 2019. The intervention group (O–Mg) received oral magnesium sulfate 1 mL/kg/day daily for 1 month compared to the placebo. Outcome measures were constipation improvement and decrease in bowel evacuation time after 1 month.
Results
Initially, weekly bowel movements, constipation scores and stool consistency were comparable in both groups. After 1 month of regular administration of oral magnesium sulfate, the constipation score, stool frequency and consistency improved compared to the placebo group (
P
|
| doi_str_mv | 10.1007/s12519-020-00401-0 |
| format | article |
| fullrecord | <record><control><sourceid>wanfang_jour_cross</sourceid><recordid>TN_cdi_wanfang_journals_ssekzz202101015</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><wanfj_id>ssekzz202101015</wanfj_id><sourcerecordid>ssekzz202101015</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-7a9b75d8f451634f9ddd611c0cc8760aec7a25089c64edc8b367d0aec89e10b73</originalsourceid><addsrcrecordid>eNp9kM1KxDAUhYsoOP68gKvsXFVv2mmSupPBPxDc6DrcSdIxY5uUJIPMvIPvbOoI7uQu7snlOydwiuKCwhUF4NeRVg1tS6igBJgDLeGgmFHBeAlM8MOsOYhSNKw9Lk5iXAOwijKYFV93XWcVqi3xHfEBezLgyploNwNJ7ybguCXWTZKkYDANxqUJVe_BO6uI8i4mO2Ky3k1gHDG_890Es5ziRuzjNuO218G4G4IkoNN-sDujJ3cKvu-zTMFif1YcdZk357_7tHi7v3tdPJbPLw9Pi9vnUtW8TSXHdskbLbp5Q1k971qtNaNUgVKCM0CjOFYNiFaxudFKLGvG9XQWraGw5PVpcbnP_UTXoVvJtd8El3-UMZqP3a6CikKeJpPVnlTBxxhMJ8dgBwxbSUFO1ct99TJXL3-ql5BN9d4UM-xWJvzl_-P6BmwSilI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial</title><source>Springer Nature</source><creator>Hassanein, Sahar M. A. ; Deifallah, Shaymaa M. ; Bastawy, Hend A.</creator><creatorcontrib>Hassanein, Sahar M. A. ; Deifallah, Shaymaa M. ; Bastawy, Hend A.</creatorcontrib><description>Background
Constipation is a common problem in children with spastic cerebral palsy (sCP) with a prevalence that reaches 75%. We hypothesized that treating constipation in those children will improve their health and shorten time spent in daily care. Our aim was to evaluate the efficacy and safety of oral magnesium sulfate for treating chronic constipation in children with sCP.
Methods
A prospective, double-blinded randomized control trial was carried out involving 100 children aged 2–12 years with sCP (level III–V of the Gross Motor Functional Classification system) and chronic constipation. They were followed up in the Pediatric neurology clinic, Children’s hospital, Ain Shams University, May 2017- January 2019. The intervention group (O–Mg) received oral magnesium sulfate 1 mL/kg/day daily for 1 month compared to the placebo. Outcome measures were constipation improvement and decrease in bowel evacuation time after 1 month.
Results
Initially, weekly bowel movements, constipation scores and stool consistency were comparable in both groups. After 1 month of regular administration of oral magnesium sulfate, the constipation score, stool frequency and consistency improved compared to the placebo group (
P
< 0.001). Effective safe treatment was achieved in 31 (68%) and 4 (9.5%) patients in the O–Mg and placebo groups, respectively (RR, 2.95; 95% CI 2.0–4.5) (
P
< 0.001). Painful bowel evacuation attempts spent by mothers decreased from 25 (55.6%) of the cases initially to 10 (22%) cases after one month in the O–Mg group (
P
= 0.001). In contrast, in the placebo group, the decrease went from 21 (50%) cases initially to 18 (42.9%) after 1 month and was not significant (
P
= 0.5).
Conclusions
Oral magnesium sulfate seems effective in alleviating chronic constipation and pain experience in children with sCP. Consequently, saving maternal time spent in daily bowel evacuation attempts.</description><identifier>ISSN: 1708-8569</identifier><identifier>EISSN: 1867-0687</identifier><identifier>DOI: 10.1007/s12519-020-00401-0</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Critical Care Medicine ; Imaging ; Intensive ; Maternal and Child Health ; Medicine ; Medicine & Public Health ; Original Article ; Pediatric Surgery ; Pediatrics ; Radiology ; Surgery</subject><ispartof>World journal of pediatrics : WJP, 2021-02, Vol.17 (1), p.92-98</ispartof><rights>Children's Hospital, Zhejiang University School of Medicine 2021</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-7a9b75d8f451634f9ddd611c0cc8760aec7a25089c64edc8b367d0aec89e10b73</citedby><cites>FETCH-LOGICAL-c379t-7a9b75d8f451634f9ddd611c0cc8760aec7a25089c64edc8b367d0aec89e10b73</cites><orcidid>0000-0002-0191-8425</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/ssekzz/ssekzz.jpg</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Hassanein, Sahar M. A.</creatorcontrib><creatorcontrib>Deifallah, Shaymaa M.</creatorcontrib><creatorcontrib>Bastawy, Hend A.</creatorcontrib><title>Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial</title><title>World journal of pediatrics : WJP</title><addtitle>World J Pediatr</addtitle><description>Background
Constipation is a common problem in children with spastic cerebral palsy (sCP) with a prevalence that reaches 75%. We hypothesized that treating constipation in those children will improve their health and shorten time spent in daily care. Our aim was to evaluate the efficacy and safety of oral magnesium sulfate for treating chronic constipation in children with sCP.
Methods
A prospective, double-blinded randomized control trial was carried out involving 100 children aged 2–12 years with sCP (level III–V of the Gross Motor Functional Classification system) and chronic constipation. They were followed up in the Pediatric neurology clinic, Children’s hospital, Ain Shams University, May 2017- January 2019. The intervention group (O–Mg) received oral magnesium sulfate 1 mL/kg/day daily for 1 month compared to the placebo. Outcome measures were constipation improvement and decrease in bowel evacuation time after 1 month.
Results
Initially, weekly bowel movements, constipation scores and stool consistency were comparable in both groups. After 1 month of regular administration of oral magnesium sulfate, the constipation score, stool frequency and consistency improved compared to the placebo group (
P
< 0.001). Effective safe treatment was achieved in 31 (68%) and 4 (9.5%) patients in the O–Mg and placebo groups, respectively (RR, 2.95; 95% CI 2.0–4.5) (
P
< 0.001). Painful bowel evacuation attempts spent by mothers decreased from 25 (55.6%) of the cases initially to 10 (22%) cases after one month in the O–Mg group (
P
= 0.001). In contrast, in the placebo group, the decrease went from 21 (50%) cases initially to 18 (42.9%) after 1 month and was not significant (
P
= 0.5).
Conclusions
Oral magnesium sulfate seems effective in alleviating chronic constipation and pain experience in children with sCP. Consequently, saving maternal time spent in daily bowel evacuation attempts.</description><subject>Critical Care Medicine</subject><subject>Imaging</subject><subject>Intensive</subject><subject>Maternal and Child Health</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Radiology</subject><subject>Surgery</subject><issn>1708-8569</issn><issn>1867-0687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kM1KxDAUhYsoOP68gKvsXFVv2mmSupPBPxDc6DrcSdIxY5uUJIPMvIPvbOoI7uQu7snlOydwiuKCwhUF4NeRVg1tS6igBJgDLeGgmFHBeAlM8MOsOYhSNKw9Lk5iXAOwijKYFV93XWcVqi3xHfEBezLgyploNwNJ7ybguCXWTZKkYDANxqUJVe_BO6uI8i4mO2Ky3k1gHDG_890Es5ziRuzjNuO218G4G4IkoNN-sDujJ3cKvu-zTMFif1YcdZk357_7tHi7v3tdPJbPLw9Pi9vnUtW8TSXHdskbLbp5Q1k971qtNaNUgVKCM0CjOFYNiFaxudFKLGvG9XQWraGw5PVpcbnP_UTXoVvJtd8El3-UMZqP3a6CikKeJpPVnlTBxxhMJ8dgBwxbSUFO1ct99TJXL3-ql5BN9d4UM-xWJvzl_-P6BmwSilI</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Hassanein, Sahar M. A.</creator><creator>Deifallah, Shaymaa M.</creator><creator>Bastawy, Hend A.</creator><general>Springer Singapore</general><general>Pediatric Department,Pediatric Neuropsychiatry Unit,Faculty of Medicine,Ain Shams University,Abbassia Square,P.O.Box 11381,Cairo,Egypt%Ministry of Health,Cairo,Egypt</general><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><orcidid>https://orcid.org/0000-0002-0191-8425</orcidid></search><sort><creationdate>20210201</creationdate><title>Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial</title><author>Hassanein, Sahar M. A. ; Deifallah, Shaymaa M. ; Bastawy, Hend A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-7a9b75d8f451634f9ddd611c0cc8760aec7a25089c64edc8b367d0aec89e10b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Critical Care Medicine</topic><topic>Imaging</topic><topic>Intensive</topic><topic>Maternal and Child Health</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Radiology</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hassanein, Sahar M. A.</creatorcontrib><creatorcontrib>Deifallah, Shaymaa M.</creatorcontrib><creatorcontrib>Bastawy, Hend A.</creatorcontrib><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>World journal of pediatrics : WJP</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hassanein, Sahar M. A.</au><au>Deifallah, Shaymaa M.</au><au>Bastawy, Hend A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial</atitle><jtitle>World journal of pediatrics : WJP</jtitle><stitle>World J Pediatr</stitle><date>2021-02-01</date><risdate>2021</risdate><volume>17</volume><issue>1</issue><spage>92</spage><epage>98</epage><pages>92-98</pages><issn>1708-8569</issn><eissn>1867-0687</eissn><abstract>Background
Constipation is a common problem in children with spastic cerebral palsy (sCP) with a prevalence that reaches 75%. We hypothesized that treating constipation in those children will improve their health and shorten time spent in daily care. Our aim was to evaluate the efficacy and safety of oral magnesium sulfate for treating chronic constipation in children with sCP.
Methods
A prospective, double-blinded randomized control trial was carried out involving 100 children aged 2–12 years with sCP (level III–V of the Gross Motor Functional Classification system) and chronic constipation. They were followed up in the Pediatric neurology clinic, Children’s hospital, Ain Shams University, May 2017- January 2019. The intervention group (O–Mg) received oral magnesium sulfate 1 mL/kg/day daily for 1 month compared to the placebo. Outcome measures were constipation improvement and decrease in bowel evacuation time after 1 month.
Results
Initially, weekly bowel movements, constipation scores and stool consistency were comparable in both groups. After 1 month of regular administration of oral magnesium sulfate, the constipation score, stool frequency and consistency improved compared to the placebo group (
P
< 0.001). Effective safe treatment was achieved in 31 (68%) and 4 (9.5%) patients in the O–Mg and placebo groups, respectively (RR, 2.95; 95% CI 2.0–4.5) (
P
< 0.001). Painful bowel evacuation attempts spent by mothers decreased from 25 (55.6%) of the cases initially to 10 (22%) cases after one month in the O–Mg group (
P
= 0.001). In contrast, in the placebo group, the decrease went from 21 (50%) cases initially to 18 (42.9%) after 1 month and was not significant (
P
= 0.5).
Conclusions
Oral magnesium sulfate seems effective in alleviating chronic constipation and pain experience in children with sCP. Consequently, saving maternal time spent in daily bowel evacuation attempts.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><doi>10.1007/s12519-020-00401-0</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0191-8425</orcidid></addata></record> |
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| language | eng |
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| source | Springer Nature |
| subjects | Critical Care Medicine Imaging Intensive Maternal and Child Health Medicine Medicine & Public Health Original Article Pediatric Surgery Pediatrics Radiology Surgery |
| title | Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial |
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