Detection of Left Ventricular Regional Relaxation Abnormalities in Patients with Hypertrophic Cardiomyopathy by Quantitative Tissue Velocity Imaging

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences 2004, Vol.24 (2), p.185-188
• Main Author: 潘敏 邓又斌 常青 杨好意 毕小军 向慧娟 黎春蕾
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Cardiomyopathy, Hypertrophic - diagnostic imaging; Cardiomyopathy, Hypertrophic - physiopathology; Child; Diastole; Echocardiography, Doppler, Color - methods; Female; Humans; Hypertrophy, Left Ventricular - diagnostic imaging; Hypertrophy, Left Ventricular - physiopathology; Male; Middle Aged; Ventricular Function, Left; 定量显像分析; 左心室舒张畸形; 心脏收缩功能; 肥厚型心肌病
• ISSN: 1672-0733; 1993-1352

To assess the left ventricular regional relaxation abnormalities in patients with hypertrophic cardiomyopathy (HCM) by quantitative tissue velocity imaging (QTVI), Doppler eehocar-diography and QTVI were performed in HCM (n=10) and healthy subjects (n=11) at apical long-axis, two-chamber and four-chamber views. Regional early diastolic velocity (rVe) and regional at-rial contraction (rVa) were measured at each segment of ventrieular middle, basal and annular levels. Mean rVe and mean rVa at three levels as well as mean rVe/rVa ratio were calculated. Our results showed that transmitral inflow peak velocities during early diastole (E) and atrial contraction(A) were also measured and E/A ratio was calculated. The rVe of all left ventrieular segments in HCM were lower than those in healthy subjects (P＜0.05), but compared with healthy subjects majority of rVa in HCM were not different except inferior wall and anterior wall. E between HCM and healthy subjects was different (P=0. 036), while mean rVe between them was significantly different (P＜0. 0001 ). Mean rVa and mean rVe/rVa of three levels were lower in HCM than in healthy subjects (P＜0.05), but there were no differences in A and E/A between them (P=0.22,P=0. 101). Left ventricular regional myocardial relaxation is reduced in HCM. Transmitral inflow E and A are influenced by preload, relaxation of myocardium and atrial contraction, etc. , while rVe and rVa reflect myocardial relaxation function independently. QTVI is more sensitive and more accurate than conventional Doppler imaging for characterizingregional diastolic properties in HCM.