Role of Stem Cell Factor and Its Receptor in the Pathogenesis of Pediatric Aplastic Anemia

• Published in: Current medical science 2005, Vol.25 (1), p.29-31
• Main Author: 王军 冯建飞 王伟 胡豫 赵雪莲 王宏 朱绍先
• Format: Article
• Language: English
• Subjects: Adolescent; Anemia, Aplastic - etiology; Anemia, Aplastic - metabolism; Child; Child, Preschool; Female; Humans; Male; Receptors, Colony-Stimulating Factor - biosynthesis; Receptors, Colony-Stimulating Factor - genetics; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Stem Cell Factor - biosynthesis; Stem Cell Factor - genetics; 再生障碍性贫血; 发病机制; 干细胞
• ISSN: 1672-0733; 2096-5230; 1993-1352; 2523-899X
• DOI: 10.1007/bf02831379

In order to investigate the levels of stem cell factor (SCF) and its receptor c-kit protein and mRNA in pediatric aplastic anemia (AA) and their relevance to the pathogenesis, immunocytochemical and in situ hybridization were utilized to detect the expression of SCF and its receptor c-kit gene protein and mRNA, respectively in 59 children with AA and 51 normal controls. The relationship between SCF and c-kit and the pathogenesis of AA was analyzed subsequently. The results showed that the positive rate of SCF protein and mRNA expression in children with AA was significantly lower than that in healthy controls (P0.05). It was concluded that the expression of SCF is significantly decreased in children with AA, which may be closely associated with the pathogenesis of the AA. c-kit may be unrelated to the development of pediatric AA. Therefore, AA in children may have abnormalities at SCF/c-kit signal transduction levels.