Effects of Intestinal Trefoil Factor on Colonic Mucosa in Experimental Colitis of Rats

In order to investigate the protective effects of intestinal trefoil factor (ITF) on colonic mucosa in experimental colitis of rats, ITF was detected by RT-PCR and immunohistoehemistry at different time points. Three days after colitis induction, rats were treated with either 0.9% saline solution or...

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Bibliographic Details
Published in:Current medical science 2005, Vol.25 (3), p.300-302
Main Author: 杨天 邹开芳 钱伟
Format: Article
Language:English
Subjects:
Acetic Acid
Animals
Colitis - chemically induced
Colitis - drug therapy
Colitis - metabolism
Colon - metabolism
Female
Intestinal Mucosa - metabolism
Male
Malondialdehyde - metabolism
Nitric Oxide Synthase Type II - biosynthesis
Nitric Oxide Synthase Type II - genetics
Peptides - analysis
Peptides - pharmacology
Peptides - therapeutic use
Random Allocation
Rats
Rats, Sprague-Dawley
Recombinant Proteins - pharmacology
Recombinant Proteins - therapeutic use
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Superoxide Dismutase - biosynthesis
Superoxide Dismutase - genetics
Trefoil Factor-2
动物实验
大肠炎
结肠黏膜
肠内生长
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Summary:In order to investigate the protective effects of intestinal trefoil factor (ITF) on colonic mucosa in experimental colitis of rats, ITF was detected by RT-PCR and immunohistoehemistry at different time points. Three days after colitis induction, rats were treated with either 0.9% saline solution or rhITF. Pathological changes and the expression of iNOS mRNA, NO, MDA and SOD were measured respectively. It was found that ITF was mainly located in goblet cells, significantly higher in model group than in normal group (P
ISSN:1672-0733
2096-5230
1993-1352
2523-899X
DOI:10.1007/bf02828149