Effects of Ligustrazine on the Contraction of Isolated Rabbit Corpus Cavernosum Strips

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences 2005, Vol.25 (5), p.565-567
• Main Author: 肖恒军 刘继红 尹春萍 王涛 陈俊 樊龙昌 叶章群
• Format: Article
• Language: English
• Subjects: Animals; Calcium Channels - drug effects; In Vitro Techniques; Male; Muscle Contraction - drug effects; Muscle Relaxation - drug effects; Muscle, Smooth - drug effects; Muscle, Smooth - physiology; Penis - drug effects; Penis - physiology; Phenylephrine - pharmacology; Potassium Chloride - pharmacology; Pyrazines - pharmacology; Rabbits; 动物实验; 川弓嗪; 肌肉收缩; 钙离子
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/bf02896019

Summary： To investigate the role of ligustrazine on relaxation of the isolated rabbit corpus cavernosum tissue in vitro, the effects of ligustrazine on the corpus cavernosum were observed by using experimental method of smooth muscle strips. Concentration-responses to phenylephine （PE） and KCI were recorded. The results showed that ligustrazine concentration-dependently depressed the contraction response of smooth muscle strips induced by PE. The maximum percentage relaxation of cavernosal strips by ligustrazine was 74.1±6.2 % （compared with control： 21.9±5.6%, P〈0.01）. Ligustrazine concentration-dependently reduced the amplitude of the contraction induced by cumulative doses of PE or KCI, shifted the cumulative concentration response curves of PE and KCI to the right and depressed their maximal responses. It was concluded that ligustrazine could significantly relax the cavernosal muscle contraction induced by PE in vitro. The results suggested that ligustrazine inhibited calcium ion influx.