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Expression of Th17 cytokines in skin lesions of patients with psoriasis
In order to investigate the role of Th17 cytokines in the pathogenesis of psoriasis, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the expression of IL-17, IL-23 (p19/p40), and IL-6 in skin lesions and non-lesions of the patients with psoriasis and skin tissues of norma...
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Published in: | Journal of Huazhong University of Science and Technology. Medical sciences 2007-06, Vol.27 (3), p.330-332 |
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description | In order to investigate the role of Th17 cytokines in the pathogenesis of psoriasis, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the expression of IL-17, IL-23 (p19/p40), and IL-6 in skin lesions and non-lesions of the patients with psoriasis and skin tissues of normal subjects. The results showed that the mRNA expression levels of IL-17, IL-23p19, IL-23p40 and IL-6 in psoriasis lesion were significantly higher than those of non-lesions (1.231 +/- 0.843 vs 1.003 +/- 0.044, 1.166 +/- 0.142 vs 0.765 +/- 0.133, 1.125 +/- 0.104 vs 0.730 +/- 0.103, 1.186 +/- 0.222 vs 0.976 +/- 0.122, respectively, all P < 0.05). Meanwhile, The expression levels of IL-17 mRNA, IL-23p19 mRNA, IL-23p40 mRNA and IL-6 mRNA were higher in non-lesions than those in normal skin tissues (1.003 +/- 0.044 vs 0.620 +/- 0.104, 0.765 +/- 0.133 vs 0.584 +/- 0.078, 0.730 +/- 0.103 vs 0.000 +/- 0.000, 0.976 +/- 0.122 vs 0.656 +/- 0.121, respectively, all P < 0.05). The overexpression of Th17 cytokines in the skin lesions of patients with psoriasis may indicate that Th17 cytokines play a very important role in the immunopathogenesis of psoriasis. |
doi_str_mv | 10.1007/s11596-007-0329-1 |
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The results showed that the mRNA expression levels of IL-17, IL-23p19, IL-23p40 and IL-6 in psoriasis lesion were significantly higher than those of non-lesions (1.231 +/- 0.843 vs 1.003 +/- 0.044, 1.166 +/- 0.142 vs 0.765 +/- 0.133, 1.125 +/- 0.104 vs 0.730 +/- 0.103, 1.186 +/- 0.222 vs 0.976 +/- 0.122, respectively, all P < 0.05). Meanwhile, The expression levels of IL-17 mRNA, IL-23p19 mRNA, IL-23p40 mRNA and IL-6 mRNA were higher in non-lesions than those in normal skin tissues (1.003 +/- 0.044 vs 0.620 +/- 0.104, 0.765 +/- 0.133 vs 0.584 +/- 0.078, 0.730 +/- 0.103 vs 0.000 +/- 0.000, 0.976 +/- 0.122 vs 0.656 +/- 0.121, respectively, all P < 0.05). The overexpression of Th17 cytokines in the skin lesions of patients with psoriasis may indicate that Th17 cytokines play a very important role in the immunopathogenesis of psoriasis.</description><identifier>ISSN: 1672-0733</identifier><identifier>EISSN: 1993-1352</identifier><identifier>DOI: 10.1007/s11596-007-0329-1</identifier><identifier>PMID: 17641855</identifier><language>eng</language><publisher>China: Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China</publisher><subject>Adult ; Female ; Gene Expression ; Humans ; Interleukin-17 - genetics ; Interleukin-23 - genetics ; Interleukin-6 - genetics ; Keratinocytes - metabolism ; Male ; Psoriasis - genetics ; Psoriasis - pathology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Skin - metabolism ; Skin - pathology ; T-Lymphocyte Subsets - metabolism ; T-Lymphocyte Subsets - pathology</subject><ispartof>Journal of Huazhong University of Science and Technology. Medical sciences, 2007-06, Vol.27 (3), p.330-332</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-57906fb299c2701becb20180a1d413ae2779d6187ce597293e550376b489d3873</citedby><cites>FETCH-LOGICAL-c335t-57906fb299c2701becb20180a1d413ae2779d6187ce597293e550376b489d3873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/tjykdxxb-e/tjykdxxb-e.jpg</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17641855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jiawen</creatorcontrib><creatorcontrib>Chen, Xu'e</creatorcontrib><creatorcontrib>Liu, Zhixiang</creatorcontrib><creatorcontrib>Yue, Qing</creatorcontrib><creatorcontrib>Liu, Houjun</creatorcontrib><title>Expression of Th17 cytokines in skin lesions of patients with psoriasis</title><title>Journal of Huazhong University of Science and Technology. Medical sciences</title><addtitle>J Huazhong Univ Sci Technolog Med Sci</addtitle><description>In order to investigate the role of Th17 cytokines in the pathogenesis of psoriasis, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the expression of IL-17, IL-23 (p19/p40), and IL-6 in skin lesions and non-lesions of the patients with psoriasis and skin tissues of normal subjects. The results showed that the mRNA expression levels of IL-17, IL-23p19, IL-23p40 and IL-6 in psoriasis lesion were significantly higher than those of non-lesions (1.231 +/- 0.843 vs 1.003 +/- 0.044, 1.166 +/- 0.142 vs 0.765 +/- 0.133, 1.125 +/- 0.104 vs 0.730 +/- 0.103, 1.186 +/- 0.222 vs 0.976 +/- 0.122, respectively, all P < 0.05). Meanwhile, The expression levels of IL-17 mRNA, IL-23p19 mRNA, IL-23p40 mRNA and IL-6 mRNA were higher in non-lesions than those in normal skin tissues (1.003 +/- 0.044 vs 0.620 +/- 0.104, 0.765 +/- 0.133 vs 0.584 +/- 0.078, 0.730 +/- 0.103 vs 0.000 +/- 0.000, 0.976 +/- 0.122 vs 0.656 +/- 0.121, respectively, all P < 0.05). The overexpression of Th17 cytokines in the skin lesions of patients with psoriasis may indicate that Th17 cytokines play a very important role in the immunopathogenesis of psoriasis.</description><subject>Adult</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Interleukin-17 - genetics</subject><subject>Interleukin-23 - genetics</subject><subject>Interleukin-6 - genetics</subject><subject>Keratinocytes - metabolism</subject><subject>Male</subject><subject>Psoriasis - genetics</subject><subject>Psoriasis - pathology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><subject>T-Lymphocyte Subsets - metabolism</subject><subject>T-Lymphocyte Subsets - pathology</subject><issn>1672-0733</issn><issn>1993-1352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpFkLFOwzAURS0EoqXwASwoEwsy-NmxHY8IlYJUiaXMlpM41G2ahLxEbf-eRK3E9O5w7n3SIeQe2DMwpl8QQBpFh0iZ4IbCBZmCMYKCkPxyyEpzyrQQE3KDuGFMasXjazIBrWJIpJySxfzQtB4x1FVUF9FqDTrKjl29DZXHKFQRDikq_QjgSDSuC77qMNqHbh01WLfBYcBbclW4Ev3d-c7I9_t89fZBl1-Lz7fXJc2EkB2V2jBVpNyYjGsGqc9SziBhDvIYhPNca5MrSHTmpdHcCC8lE1qlcWJykWgxI0-n3b2rClf92E3dt9Xw0Xab4zY_HFLr-SCECTa0Z-TxRDdt_dt77OwuYObL0lW-7tFqprlUSgwgnMCsrRFbX9imDTvXHi0wO7q2J9d2jKNrC0Pn4Tzepzuf_zfOcsUf6FZ4Rg</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Li, Jiawen</creator><creator>Chen, Xu'e</creator><creator>Liu, Zhixiang</creator><creator>Yue, Qing</creator><creator>Liu, Houjun</creator><general>Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20070601</creationdate><title>Expression of Th17 cytokines in skin lesions of patients with psoriasis</title><author>Li, Jiawen ; Chen, Xu'e ; Liu, Zhixiang ; Yue, Qing ; Liu, Houjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-57906fb299c2701becb20180a1d413ae2779d6187ce597293e550376b489d3873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Interleukin-17 - genetics</topic><topic>Interleukin-23 - genetics</topic><topic>Interleukin-6 - genetics</topic><topic>Keratinocytes - metabolism</topic><topic>Male</topic><topic>Psoriasis - genetics</topic><topic>Psoriasis - pathology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Skin - metabolism</topic><topic>Skin - pathology</topic><topic>T-Lymphocyte Subsets - metabolism</topic><topic>T-Lymphocyte Subsets - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Li, Jiawen</creatorcontrib><creatorcontrib>Chen, Xu'e</creatorcontrib><creatorcontrib>Liu, Zhixiang</creatorcontrib><creatorcontrib>Yue, Qing</creatorcontrib><creatorcontrib>Liu, Houjun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jiawen</au><au>Chen, Xu'e</au><au>Liu, Zhixiang</au><au>Yue, Qing</au><au>Liu, Houjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Th17 cytokines in skin lesions of patients with psoriasis</atitle><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle><addtitle>J Huazhong Univ Sci Technolog Med Sci</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>27</volume><issue>3</issue><spage>330</spage><epage>332</epage><pages>330-332</pages><issn>1672-0733</issn><eissn>1993-1352</eissn><abstract>In order to investigate the role of Th17 cytokines in the pathogenesis of psoriasis, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the expression of IL-17, IL-23 (p19/p40), and IL-6 in skin lesions and non-lesions of the patients with psoriasis and skin tissues of normal subjects. The results showed that the mRNA expression levels of IL-17, IL-23p19, IL-23p40 and IL-6 in psoriasis lesion were significantly higher than those of non-lesions (1.231 +/- 0.843 vs 1.003 +/- 0.044, 1.166 +/- 0.142 vs 0.765 +/- 0.133, 1.125 +/- 0.104 vs 0.730 +/- 0.103, 1.186 +/- 0.222 vs 0.976 +/- 0.122, respectively, all P < 0.05). Meanwhile, The expression levels of IL-17 mRNA, IL-23p19 mRNA, IL-23p40 mRNA and IL-6 mRNA were higher in non-lesions than those in normal skin tissues (1.003 +/- 0.044 vs 0.620 +/- 0.104, 0.765 +/- 0.133 vs 0.584 +/- 0.078, 0.730 +/- 0.103 vs 0.000 +/- 0.000, 0.976 +/- 0.122 vs 0.656 +/- 0.121, respectively, all P < 0.05). The overexpression of Th17 cytokines in the skin lesions of patients with psoriasis may indicate that Th17 cytokines play a very important role in the immunopathogenesis of psoriasis.</abstract><cop>China</cop><pub>Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China</pub><pmid>17641855</pmid><doi>10.1007/s11596-007-0329-1</doi><tpages>3</tpages></addata></record> |
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subjects | Adult Female Gene Expression Humans Interleukin-17 - genetics Interleukin-23 - genetics Interleukin-6 - genetics Keratinocytes - metabolism Male Psoriasis - genetics Psoriasis - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Skin - metabolism Skin - pathology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology |
title | Expression of Th17 cytokines in skin lesions of patients with psoriasis |
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