Expression and Prognostic Significance of Livin in the Progression of Bladder Cancer

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences 2008-02, Vol.28 (1), p.90-92
• Main Author: 朱朝辉 王艳波 丁小博 曾甫清 徐凯
• Format: Article
• Language: English
• Subjects: Adaptor Proteins, Signal Transducing - biosynthesis; Adaptor Proteins, Signal Transducing - physiology; Adult; Aged; Aged, 80 and over; Apoptosis; Carcinoma, Transitional Cell - diagnosis; Carcinoma, Transitional Cell - metabolism; Carcinoma, Transitional Cell - pathology; Disease Progression; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins - biosynthesis; Inhibitor of Apoptosis Proteins - physiology; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Proteins - biosynthesis; Neoplasm Proteins - physiology; Prognosis; Urinary Bladder Neoplasms - diagnosis; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology; 免疫化学; 定量检测; 治疗方法; 膀胱癌
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-008-0123-8

It has been suggested that progression of bladder transitional cell cancer （BTCC） may be regulated at the molecular level by a typical pattern of expression of genes involved in apoptosis. Recently Livin, belonging to the inhibitors of apoptosis （IAP） family, has been found to be expressed in most solid tumors, where its expression is suggested to have clinical significance. In order to explore the significance of Livin expression in the development of BTCC, immunohistochemistry and RT-QPCR were used to detect the expression of Livin mRNA in tumor tissues and adjacent normal tissues of 30 cases of BTCC. The results showed that the positive rate of Livin expression in adjacent normal tissues and tumor tissues was 0 and 60% （18/30） respectively. The -△△CT value of Livin in BTCC tissues was 8.0454 （7.4264-8.6644） times of that in adjacent normal tissues. The expression of Livin mRNA had no correlation with tumor pathological grades and clinical stages. It was suggested that there was weak expression of Livin mRNA in adjacent normal tissues, but strong in tumor tissues.