Correlation between the Expression of Aquaporin 1 and Hypoxia-inducible Factor 1 in Breast Cancer Tissues

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences 2008-06, Vol.28 (3), p.346-348
• Main Author: 殷铁军 于世英 肖亮 张君 刘聪 卢运萍 刘承平
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aquaporin 1 - biosynthesis; Breast Neoplasms - metabolism; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1 - metabolism; Immunohistochemistry - methods; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Metastasis; Signal Transduction; 乳腺癌; 基因表达; 相互关系; 缺氧诱导因子
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-008-0327-y

The correlation between aquaporin 1 （AQP1） and hypoxia-inducible factor 1 （HIF 1） in breast cancer tissues was preliminarily studied. In 155 cases of breast cancer, the expression levels of AQP1 were detected by immunohistochemisty in HIFl-positive group or HIFl-negative group, and the correlation between AQP1 and HIF1 was analyzed. The overexpression of AQP1 and HIF1 were observed in 155 cases of breast cancer tissues. The expression level of AQP1 in HIFl-positive group was significantly higher than that in HIFl-negative group. The positive expression rate of AQP1 was 296.55±24.67 and 168.37±37.53 in HIFl-positive group and HIFl-negative group respectively with the difference being very significant between them （P〈0.001）. It was concluded that AQP1 was overexpressed in the HIFl-positive group and there were some correlations between AQP1 and HIF1, suggesting they interact each other and regulate the oncogenesis of breast cancer.