Up-regulated Expression of Tim-3/Gal-9 at Maternal-fetal Interface in Pregnant Woman with Recurrent Spontaneous Abortion

The relationship between T cell immunoglobulin domain and mucin domain protein 3（Tim-3）/Galectin（Gal）-9 pathway and recurrent spontaneous abortion（RSA） was studied. Thirty-one pregnant women with RSA and 27 normal early gravidas were investigated to detect the levels of Tim-3 and Gal-9 in villi and...

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Bibliographic Details
Published in:Journal of Huazhong University of Science and Technology. Medical sciences 2014-08, Vol.34 (4), p.586-590
Main Author: 李静 李璠璠 左伟 周媛 郝海燕 党静 蒋敏 何梦舟 邓东锐
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - metabolism
Abortion, Spontaneous - pathology
Adolescent
Adult
Chorionic Villi - metabolism
Chorionic Villi - pathology
Female
Galectins - biosynthesis
Hepatitis A Virus Cellular Receptor 2
Humans
Interleukin-12 - blood
Interleukin-4 - blood
Medicine
Medicine & Public Health
Membrane Proteins - biosynthesis
Pregnancy
Pregnancy Proteins - biosynthesis
RSA
Up-Regulation
Western印迹
习惯性流产
半乳糖凝集素
反复自然流产
孕妇
界面
血浆浓度
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Summary:The relationship between T cell immunoglobulin domain and mucin domain protein 3（Tim-3）/Galectin（Gal）-9 pathway and recurrent spontaneous abortion（RSA） was studied. Thirty-one pregnant women with RSA and 27 normal early gravidas were investigated to detect the levels of Tim-3 and Gal-9 in villi and deciduas by Western blotting. Meanwhile, the concentration of interleukin（IL）-4 and IL-12 in peripheral blood plasma was determined by ELISA in 25 healthy fertile non-pregnant controls, the normal early gravidas and pregnant women with RSA mentioned above, respectively. It was found that the relative expression levels of Tim-3 and Gal-9 in villi and deciduas were significantly increased in pregnant women with RSA as compared with those in the normal early gravidas. The concentration of IL-4 in peripheral blood plasma of pregnant women with RSA was lower than that of the normal early gravidas（P〈0.05） and healthy fertile non-pregnant controls（P〈0.05）, but that of IL-2 in pregnant women with RSA was significantly higher than that of the normal early gravidas（P〈0.05） and healthy fertile non-pregnant controls（P〈0.05）. It was suggested that the overexpression of Tim-3/Gal-9 pathway may be related to the pathogenesis of RSA.
ISSN:1672-0733
1993-1352
DOI:10.1007/s11596-014-1320-2