Maternal Periodontal Disease and Risk of Preeclampsia： A Meta-analysis

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences 2014-10, Vol.34 (5), p.729-735
• Main Author: 黄希 王娟 刘健 华立 张丹 胡婷 葛自力
• Format: Article
• Language: English
• Subjects: Adult; Female; Humans; Medicine; Medicine & Public Health; Meta分析; Observational Studies as Topic; Odds Ratio; Periodontal Diseases - physiopathology; Pre-Eclampsia - physiopathology; Pregnancy; Pregnancy Complications - physiopathology; PubMed; Risk Assessment - statistics & numerical data; Risk Factors; 产妇; 先兆; 子痫; 牙周疾病; 牙周病; 风险
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-014-1343-8

Research on the association between maternal periodontal disease and the risk of pree- clampsia has generated inconsistent results. This meta-analysis was conducted to evaluate the asso- ciation between maternal periodontal disease and the risk of preeclampsia. A literature search of PubMed and Embase was performed to identify relevant papers published before March 2013. Only observational studies that assessed maternal periodontal disease and the risk of preeclampsia were selected. Patients＇ periodontal status was examined at different time points during pregnancy or after delivery （at 14-32 weeks of gestation, within 48 h prior to or within 5 days after delivery）. Pooled odds ratios （ORs） and corresponding 95% confidence intervals （CIs） were calculated for cases and controls. Cases were defined as women with concurrent hypertension and proteinuria after 20 weeks of gestation. Eleven studies involving 1118 women with preeclampsia and 2798 women without preeclampsia were identified and analyzed. Women with periodontal disease before 32 weeks of ges- tation had a 3.69-fold higher risk of developing preeclampsia than their counterparts without perio- dontal disease （OR=3.69; 95% CI=2.58-5.27）. Periodontal disease within 48 h prior to delivery was associated with a 2.68-fold higher risk of preeclampsia （OR=2.68; 95% CI=1.39-5.18）. Pregnant women with periodontal disease within 5 days after delivery had a 2.22-fold higher risk of pree- clampsia than women without periodontal disease （OR=2.22; 95% CI= 1.16-4.27）. In conclusion, this meta-analysis suggests that maternal periodontal disease is an independent predictor ofpreeclampsia.