Association of Serum Dkk-1 Levels with β-catenin in Patients with Postmenopausal Osteoporosis

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences 2015-04, Vol.35 (2), p.212-218
• Main Author: 田峻 徐晓娟 沈霖 杨艳萍 朱锐 帅波 朱习文 李成刚 马陈 吕林
• Format: Article
• Language: English
• Subjects: beta Catenin - blood; ELISA法; Female; Humans; Intercellular Signaling Peptides and Proteins - blood; Medicine; Medicine & Public Health; Middle Aged; Osteoporosis, Postmenopausal - blood; 协会; 多元回归分析; 清水; 绝经后; 血清; 负相关性; 骨质疏松症
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-015-1413-6

Wnt signaling plays an important role in the bone development and remodeling. The Wnt antagonist Dkk-1 is a potent inhibitor of bone formation. The aims of this study were firstly to compare the serum Dkk-1 levels in postmenopausal osteoporosis patients with age-matched healthy controls, and secondly, to assess the possible relationship between Dkk-1 and β-catenin, sclerostin, or bone turnover markers [CTX, PINP, N-MID-OT and 25（OH）D] in the setting of postmenopausal osteoporosis. A total of 350 patients with postmenopausal osteoporosis and 150 age-matched healthy controls were enrolled, and the serum levels of Dkk-1, β-catenin, sclerostin, OPG, and RANKL were detected by ELISA, and bone turnover markers [CTX, PINP, N-MID-OT and 25（OH）D] were measured by Roche electrochemiluminescence system in two groups. Serum Dkk-1 levels were significantly higher in postmenopausal osteoporosis group than in control group（P〈0.001）. Univariate analyses revealed that serum Dkk-1 levels were weakly negatively correlated to β-catenin（r=–0.161, P=0.003） and OPG（r=–0.106, P=0.047）, while multiple regression analysis showed a negative correlation between serum Dkk-1 levels with β-catenin（β=–0.165, P=0.009） and BMD（β=–0.139, P=0.027）, and a positive correlation between serum Dkk-1 levels and CTX（β=0.122, P=0.040） in postmenopausal osteoporosis group. No similar correlations ware observed in control group. The results provided evidence for the role of Dkk-1 in bone metabolism and demonstrated the link of Dkk-1 and Wnt/β-catenin in some ways.