Association between EGF ＋61 A〉G Polymorphism and Gastric Cancer Risk： A Meta-analysis

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences 2015-06, Vol.35 (3), p.327-332
• Main Author: 吴松杰 蒋思宇 吴静 熊光练
• Format: Article
• Language: English
• Subjects: Asian Continental Ancestry Group - genetics; EGF Family of Proteins - genetics; Epidermal Growth Factor - genetics; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Medicine; Medicine & Public Health; Polymorphism, Single Nucleotide; Pubmed; Regression Analysis; Stomach Neoplasms - genetics; 万方数据库; 关联性; 分层分析; 等位基因多态性; 胃癌; 表皮生长因子; 风险估计
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-015-1432-3

Previous studies suggested an association between the EGF ＋61 A〉G polymorphism and susceptibility to gastric cancer, but the results have been inconsistent. To draw a more precise risk estimation of the association, we performed a meta-analysis of published studies. Pub Med, EMBASE, Google Scholar and the Chinese Wanfang databases were systematically searched to identify relevant studies. There were 7 studies involving 1992 cases of gastric cancer and 3202 controls in this meta-analysis. Our study showed that, overall, the EGF ＋61 A〉G polymorphism was significantly associated with the increased risk of gastric cancer in allele model（G vs. A： OR=1.18, 95% CI=1.00-1.39）, dominant model（GG ＋ GA vs. AA： OR=1.28, 95% CI=1.05-1.55）, homozygous model（GG vs. AA： OR=1.31, 95% CI=1.06-1.63） and heterozygous model（GA vs. AA： OR=1.25, 95% CI=1.01-1.53）. The stratified analysis by ethnicity revealed a significant association between EGF ＋61 A〉G polymorphism and gastric cancer risks in Asians. This meta-analysis indicates that EGF ＋61 A〉G polymorphism may increase the risk of gastric cancer, especially in Asians. Large-sized, well-designed studies involving different ethnic groups should be conducted to confirm this association.