Comparison of diagnosing and staging accuracy of PET (CT) and MIBG on patients with neuroblastoma: Systemic review and meta-analysis

Summary To perform a systemic review and meta-analysis of the diagnostic accuracy of PET (CT) and metaiodobenzylguanidine (MIBG) for diagnosing neuroblastoma (NB), electronic databases were searched as well as relevant references and conference proceedings. The diagnostic accuracy of MIBG and PET (C...

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Published in:Current medical science 2017-10, Vol.37 (5), p.649-660
Main Authors: Xia, Jia, Zhang, Hang, Hu, Qun, Liu, Shuang-you, Zhang, Liu-qing, Zhang, Ai, Zhang, Xiao-ling, Wang, Ya-qin, Liu, Ai-guo
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description Summary To perform a systemic review and meta-analysis of the diagnostic accuracy of PET (CT) and metaiodobenzylguanidine (MIBG) for diagnosing neuroblastoma (NB), electronic databases were searched as well as relevant references and conference proceedings. The diagnostic accuracy of MIBG and PET (CT) was calculated for NB, primary NB, and relapse/metastasis of NB based on their sensitivity, specificity, and area under the summary receiver operating characteristic curve (AUSROC) in terms of per-lesion and per-patient data. A total of 40 eligible studies comprising 1134 patients with 939 NB lesions were considered for the meta-analysis. For the staging of NB, the per-lesion AUSROC value of MIBG was lower than that of PET (CT) [0.8064±0.0414 vs. 0.9366±0.0166 ( P
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The diagnostic accuracy of MIBG and PET (CT) was calculated for NB, primary NB, and relapse/metastasis of NB based on their sensitivity, specificity, and area under the summary receiver operating characteristic curve (AUSROC) in terms of per-lesion and per-patient data. A total of 40 eligible studies comprising 1134 patients with 939 NB lesions were considered for the meta-analysis. For the staging of NB, the per-lesion AUSROC value of MIBG was lower than that of PET (CT) [0.8064±0.0414 vs. 0.9366±0.0166 ( P &lt;0.05)]. The per-patient AUSROC value of MIBG and PET (CT) for the diagnosis of NB was 0.8771±0.0230 and 0.6851±0.2111, respectively. The summary sensitivity for MIBG and PET (CT) was 0.79 and 0.89, respectively. The summary specificity for MIBG and PET (CT) was 0.84 and 0.71, respectively. PET (CT) showed higher per-lesion accuracy than MIBG and might be the preferred modality for the staging of NB. On the other hand, MIBG has a comparable diagnosing performance with PET (CT) in per-patient analysis but shows a better specificity.</description><identifier>ISSN: 2096-5230</identifier><identifier>ISSN: 1672-0733</identifier><identifier>EISSN: 2523-899X</identifier><identifier>EISSN: 1993-1352</identifier><identifier>DOI: 10.1007/s11596-017-1785-x</identifier><identifier>PMID: 29058276</identifier><language>eng</language><publisher>Wuhan: Huazhong University of Science and Technology</publisher><subject>Medicine ; Medicine &amp; Public Health</subject><ispartof>Current medical science, 2017-10, Vol.37 (5), p.649-660</ispartof><rights>Huazhong University of Science and Technology and Springer-Verlag GmbH Germany 2017</rights><rights>Copyright © Wanfang Data Co. Ltd. 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The diagnostic accuracy of MIBG and PET (CT) was calculated for NB, primary NB, and relapse/metastasis of NB based on their sensitivity, specificity, and area under the summary receiver operating characteristic curve (AUSROC) in terms of per-lesion and per-patient data. A total of 40 eligible studies comprising 1134 patients with 939 NB lesions were considered for the meta-analysis. For the staging of NB, the per-lesion AUSROC value of MIBG was lower than that of PET (CT) [0.8064±0.0414 vs. 0.9366±0.0166 ( P &lt;0.05)]. The per-patient AUSROC value of MIBG and PET (CT) for the diagnosis of NB was 0.8771±0.0230 and 0.6851±0.2111, respectively. The summary sensitivity for MIBG and PET (CT) was 0.79 and 0.89, respectively. The summary specificity for MIBG and PET (CT) was 0.84 and 0.71, respectively. PET (CT) showed higher per-lesion accuracy than MIBG and might be the preferred modality for the staging of NB. On the other hand, MIBG has a comparable diagnosing performance with PET (CT) in per-patient analysis but shows a better specificity.</description><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><issn>2096-5230</issn><issn>1672-0733</issn><issn>2523-899X</issn><issn>1993-1352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v1DAQhiMEolXbH8AF-ViE0vojHzY3WJW2UhFILBI3y3EmwSWxF9thN3d-eL2bAqeePNY876uZebPsFcEXBOP6MhBSiirHpM5Jzct89yw7piVlORfi-_NU49RNf3yUnYVgGswIrRjh9GV2RAUuOa2r4-zPyo0b5U1wFrkOtUb11gVje6Rsi0JU_aHWevJKz3vky9Uana_Wbw7Ap9sP1yhJNyoasDGgrYk_kIXJu2ZQIbpRvUNf5xBhNBp5-G1gexCOEFWurBrmYMJp9qJTQ4Czx_ck-_bxar26ye8-X9-u3t_lmnEc84JhYIxB3VZlVeGuqoXQZQk1bWhaDrq2LVolGlY3ggtMKXDcdK2musAVL4CdZG8X362ynbK9vHeTTzMEGe_nn-1u10ig6aC4xJgl-nyhN979miBEOZqgYRiUBTcFSURZMM4powklC6q9C8FDJzfejMrPkmC5T0suaclkLvdpyV3SvH60n5oR2n-Kv9kkgC5ASC3bg_8_7tOuD5w_oH8</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Xia, Jia</creator><creator>Zhang, Hang</creator><creator>Hu, Qun</creator><creator>Liu, Shuang-you</creator><creator>Zhang, Liu-qing</creator><creator>Zhang, Ai</creator><creator>Zhang, Xiao-ling</creator><creator>Wang, Ya-qin</creator><creator>Liu, Ai-guo</creator><general>Huazhong University of Science and Technology</general><general>Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China%Department of Biliary-Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China%Department of Hematology, Shenzhen Children's Hospital, Shenzhen 518038, China</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20171001</creationdate><title>Comparison of diagnosing and staging accuracy of PET (CT) and MIBG on patients with neuroblastoma: Systemic review and meta-analysis</title><author>Xia, Jia ; Zhang, Hang ; Hu, Qun ; Liu, Shuang-you ; Zhang, Liu-qing ; Zhang, Ai ; Zhang, Xiao-ling ; Wang, Ya-qin ; Liu, Ai-guo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-430e333e7d65660f6799c55e72b2312efdd4da9b37b989022e80bfdc2c40684e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xia, Jia</creatorcontrib><creatorcontrib>Zhang, Hang</creatorcontrib><creatorcontrib>Hu, Qun</creatorcontrib><creatorcontrib>Liu, Shuang-you</creatorcontrib><creatorcontrib>Zhang, Liu-qing</creatorcontrib><creatorcontrib>Zhang, Ai</creatorcontrib><creatorcontrib>Zhang, Xiao-ling</creatorcontrib><creatorcontrib>Wang, Ya-qin</creatorcontrib><creatorcontrib>Liu, Ai-guo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Current medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xia, Jia</au><au>Zhang, Hang</au><au>Hu, Qun</au><au>Liu, Shuang-you</au><au>Zhang, Liu-qing</au><au>Zhang, Ai</au><au>Zhang, Xiao-ling</au><au>Wang, Ya-qin</au><au>Liu, Ai-guo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of diagnosing and staging accuracy of PET (CT) and MIBG on patients with neuroblastoma: Systemic review and meta-analysis</atitle><jtitle>Current medical science</jtitle><stitle>CURR MED SCI</stitle><addtitle>J Huazhong Univ Sci Technolog Med Sci</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>37</volume><issue>5</issue><spage>649</spage><epage>660</epage><pages>649-660</pages><issn>2096-5230</issn><issn>1672-0733</issn><eissn>2523-899X</eissn><eissn>1993-1352</eissn><abstract>Summary To perform a systemic review and meta-analysis of the diagnostic accuracy of PET (CT) and metaiodobenzylguanidine (MIBG) for diagnosing neuroblastoma (NB), electronic databases were searched as well as relevant references and conference proceedings. 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title Comparison of diagnosing and staging accuracy of PET (CT) and MIBG on patients with neuroblastoma: Systemic review and meta-analysis
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