Antibiotic Resistance Genes in the Human-Impacted Environment: A One Health Perspective

Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, a...

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Bibliographic Details
Published in:Pedosphere 2019-06, Vol.29 (3), p.273-282
Main Authors: TIEDJE, James M., WANG, Fang, MANAIA, Célia M., VIRTA, Marko, SHENG, Hongjie, MA, Liping, ZHANG, Tong, TOPP, Edward
Format: Article
Language:English
Subjects:
Animal agriculture
Animal wastes
Antibiotic resistance
antibiotic-resistant bacteria
Antibiotics
Antimicrobial resistance
Aquaculture
Aquaculture effluents
Dispersal
Dispersion
Domains
Drug resistance
Environmental impact
Genes
Global health
Human health
One Health framework
soil contamination
Surveillance
wastewater and sludge
Wastewater treatment
Wastewater treatment plants
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Summary:Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components. This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal. Recently, much work has been done describing antibiotic resistance genes in various environments; now quantitative, mechanistic, and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains.
ISSN:1002-0160
2210-5107
DOI:10.1016/S1002-0160(18)60062-1