Titanium Dioxide Nanoparticle Absorbed by Hepatoma Cells in Vitro

It is reported thut nanoporticles can be applied as carriers and anti-cancer medicines. But the interaction of nanoparticles and cells is unclear. The purpose of this study was to discuss whether inorganic crystal nanoparticles can get through cells with intact crystal. BEL7402 heputoma cells and ti...

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Bibliographic Details
Published in:Journal of Wuhan University of Technology. Materials science edition 2005-09, Vol.20 (3), p.31-34
Main Authors: Hu, Sheni, Yan, Yuhua, Wang, Youfa, Cao, Xianying, Li, Shipu
Format: Article
Language:English
Subjects:
二氧化钛
晶体结构
纳米粒子
肝癌细胞
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Summary:It is reported thut nanoporticles can be applied as carriers and anti-cancer medicines. But the interaction of nanoparticles and cells is unclear. The purpose of this study was to discuss whether inorganic crystal nanoparticles can get through cells with intact crystal. BEL7402 heputoma cells and titanium dioxide （ TiO2 ） nanoporticles were selected and incubated together in vitro. All specimens were prepared and observed under a traasmission electron mieroscope （TEM）. TiO2 nanopartieles were found not in the nuclear area but in the cytoplasma. TiO2 nanoponieles maintained the plate-like shape during absorbing. The result shows that hepatoma cells can endocytose the intact TiO2 crystal nanoparticles. It implies that novel nano-effect plays an important role in the biomedicinal application of inorganic crystal nanopartieles.
ISSN:1000-2413
1993-0437
DOI:10.1007/bf02835021