p16 gene methylation in colorectal cancers associated with Duke's staging

To explore the association of methylation of the CpG island in the promotor of the p16 tumor suppressor gene with the clinicopathological characteristics of the colorectal cancers. Methylation-specific PCR (MSP) was used to detect p16 methylation of 62 sporadic colorectal cancer specimens. p16 methy...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2001-10, Vol.7 (5), p.722-725
Main Authors: Yi, J, Wang, Z W, Cang, H, Chen, Y Y, Zhao, R, Yu, B M, Tang, X M
Format: Article
Language:English
Subjects:
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
CpG Islands - genetics
DNA Methylation
Female
Genes, p16 - physiology
Humans
Male
Middle Aged
Neoplasm Staging
Polymerase Chain Reaction
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Summary:To explore the association of methylation of the CpG island in the promotor of the p16 tumor suppressor gene with the clinicopathological characteristics of the colorectal cancers. Methylation-specific PCR (MSP) was used to detect p16 methylation of 62 sporadic colorectal cancer specimens. p16 methylation was detected in 42% of the tumors.Dukes'staging was associated with p16 methylation status.p16 methylation occurred more frequently in Dukes'C and D patients (75.9%) than in Dukes'A and B patients (12.1%). p16 methylation plays a role in the carcinogenesis of a subset of colorectal cancer, and it might be linked to poor prognosis.
ISSN:1007-9327
DOI:10.3748/wjg.7.5.722