Smoking in inflammatory bowel diseases： Good, bad or ugly

Smoking is an important environmental factor in inflammatory bowel disease （IBD）, having different effects in ulcerative colitis （UC） and Crohn＇s disease （CD）. A recent meta-analysis partially confirmed previous findings that smoking was found to be protective against ulcerative colitis and, after o...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2007-12, Vol.13 (46), p.6134-6139
Main Authors: Lakatos, Peter Laszlo, Szamosi, Tamas, Lakatos, Laszlo
Format: Article
Language:English
Subjects:
Colitis, Ulcerative - physiopathology
Colitis, Ulcerative - prevention & control
Crohn Disease - etiology
Crohn Disease - physiopathology
Humans
Inflammatory Bowel Diseases - etiology
Inflammatory Bowel Diseases - physiopathology
Inflammatory Bowel Diseases - prevention & control
Risk Factors
Smoking - adverse effects
Smoking - physiopathology
Smoking Cessation
克罗恩氏病
吸烟者
溃疡性结肠炎
表现型
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Summary:Smoking is an important environmental factor in inflammatory bowel disease （IBD）, having different effects in ulcerative colitis （UC） and Crohn＇s disease （CD）. A recent meta-analysis partially confirmed previous findings that smoking was found to be protective against ulcerative colitis and, after onset of the disease, might improve its course, decreasing the need for colectomy. However, smoking increases the risk of developing Crohn＇s disease and worsens its course, increasing the need for steroids, immunosuppressants and re-operations. Smoking cessation aggravates ulcerative colitis and improves Crohn＇s disease. Data are however, largely conflictive as well as the potential mechanisms involved in this dual relationship are still unknown. In this review article, the authors review the role of smoking in inflammatory bowel diseases.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.13.6134