Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients

• Published in: Asian Pacific journal of tropical medicine 2012-06, Vol.5 (6), p.469-471
• Main Authors: Yan, Zhe, Liu, Yang, Huang, Hui
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Analysis of Variance; Cardiovascular; Cardiovascular disease; Cholesterol, HDL - metabolism; Cholesterol, LDL - metabolism; diabetes; Diabetes Mellitus, Type 2 - blood; disease; Female; Glucose Intolerance - blood; Glycated Hemoglobin A - metabolism; HbA1c; Humans; Lipid; Lipid ratio; Male; Middle Aged; ratio; Triglycerides - metabolism; Type; Type 2 diabetes
• ISSN: 1995-7645; 2352-4146
• DOI: 10.1016/S1995-7645(12)60080-7

<正>Objective:To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin(HbA1c).Methods:Samples were collected from 128 type 2 diabetic patients（aged 19-90 years;male 72,female 56）.The sera were analyzed for HbA1c,total cholesterol（TC）,triglycerides（TG）,high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C）.According to the HbA1e level,the patients were divided into three groups,group A(HbA?<7%,n=31),group B(7%<HbA1c<10%,n=48),and group C(HbA1c>10%,n=49).The correlation of HbA1cwith lipid ratios & individual lipid indexes were analyzed.Results:With the increased level of HbA（1c）,LDL-C had a significantly increasing trend（P<0.05）;whereas TC went up with the increased HbA（1c）,without any significant differences between three groups.There was no significant correlation between HbA1c and TG or HDL-C. With the increased level of HbA1c,TC/HDL-C,LDL-C/HDL-C ratios were gradually increased, with significant differences among groups（P<0.05）.The lipid ratios,especially LDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual lipid. Conclusions:LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type 2 diabetic patients.