In vivo antiplasmodial activities of ethanolic exract and fractions of Eleucine indica

<正>Objective:To evaluate the in rivo antiplasmodial activities of the extract and fractions(n-hexane. chloroform,ethylacetate.butanol.aqueous) of the whole plant in Plasmodium berghei berghei infected mice.Methods:Oral administrations of the extract(200.400,and 600 my/kg) of Eleacine i...

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Bibliographic Details
Published in:Asian Pacific journal of tropical medicine 2012-09, Vol.5 (9), p.673-676
Main Authors: Ettebong, EO, Nwafor, PA, Okokon, JE
Format: Article
Language:English
Subjects:
activity
Alkaloid
Antimalarial
Antimalarial activity
berghei
Eleucine
Eleucine indica
indica
Plasmodium
Plasmodium berghei
Plasmodium berghei berghei
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Summary:<正>Objective:To evaluate the in rivo antiplasmodial activities of the extract and fractions(n-hexane. chloroform,ethylacetate.butanol.aqueous) of the whole plant in Plasmodium berghei berghei infected mice.Methods:Oral administrations of the extract(200.400,and 600 my/kg) of Eleacine indica and fractions(400 mg/kg) were screened in the 4-day.repository and curative tests. Chloroquine(5 mg/kg).pyrimethamine(1.2 mg/kgi and artesunate(5 mg/kgi were used as controls. Results:The extract showed significant[P< 0.05-0.001) dose-dependent,antiplasmodial activity in the 4-day.repository and curative tests and increased the survival times of the infected mice. All the fractions exhibited significant antiplasmodial activity with the highest being ethylacetate fraction.Conclusions:Eleucine indica extract and fractions possess antimalarial activity which confirms the ethnobotanical use of this plant as a malarial remedy and opens a new highway to further investigate its potentials in the on-going fight against malaria.
ISSN:1995-7645
2352-4146
DOI:10.1016/S1995-7645(12)60105-9