Dauricine can inhibit the activity of proliferation of urinary tract tumor cells

• Published in: Asian Pacific journal of tropical medicine 2012-12, Vol.5 (12), p.973-976
• Main Authors: Wang, Jun, Li, Yuan, Zu, Xiong-Bing, Chen, Min-Feng, Qi, Lin
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacokinetics; Antineoplastic Agents, Phytogenic - pharmacology; Benzylisoquinolines - chemistry; Benzylisoquinolines - isolation & purification; Benzylisoquinolines - pharmacokinetics; Benzylisoquinolines - pharmacology; cell; Cell Line, Tumor; Cell Proliferation - drug effects; Dauricine; EJ cell strain; Humans; Menispermum - chemistry; PAMD; PC-3Mcell; PC-3Mcell strain; Plant Extracts - chemistry; Plant Extracts - pharmacology; Rhizome - chemistry; strain; system; Tetrahydroisoquinolines - chemistry; Tetrahydroisoquinolines - isolation & purification; Tetrahydroisoquinolines - pharmacokinetics; Tetrahydroisoquinolines - pharmacology; Urinary; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - pathology; Urinary system
• ISSN: 1995-7645; 2352-4146
• DOI: 10.1016/S1995-7645(12)60185-0

<正>Objective:To explore the anti-tumor effects of asiatic moonseed rhizome extraction-dauricine on bladder cancer EJ cell strain,prostate cancer PC-3Mcell strain and primary cell culture system.Methods:The main effective component-phenolic alkaloids of Menispermum dauricum was extracted and separated from asiatic moonseed rhizome by chemical method.MTT method was used to detect dauricine anti-tumor effect.Results:Dauricine had an obvious proliferation inhibition effect on the main tumor cells in urinary system.The minimum drug sensitivity concentration was between 3.81-S.ISμg/mL,and the inhibition ratio increased with the increase of concentration.Condusioiis:Dauricine,the main effective component extracted from asiatic moonseed rhizome,had a good inhibition effect on tumor cells in urinary system.At the same time,Dauricine has certain inhibition effects on the primary cultured tumor cell.