Protective effect of Sida cordata leaf extract against CCl4 induced acute liver toxicity in rats

• Published in: Asian Pacific journal of tropical medicine 2013-04, Vol.6 (4), p.280-284
• Main Authors: Mistry, Sunil, Dutt, KR, Jena, J
• Format: Article
• Language: English
• Subjects: CCl4; cordata; Hepatoprotective; Histopathology; Sida; Sida cordata
• ISSN: 1995-7645; 2352-4146
• DOI: 10.1016/S1995-7645(13)60057-7

<正>Objective:To investigate the hepatoprotective potential of Sida cordata（Malvaceae）（S.cordata） in experimental rats to validate its traditional claim.Methods:Wister albino rats were divided into 6 groups:Croup 1 served as control;CroupⅡserved as hepatotoxic（CCl4 treated） group; CroupⅢ,Ⅳand V served as（100,200 and 400 mg/kg b.w.） S.cordata leaf extract（SCLE） treated groups;CroupⅥserved as positive control（Silymarin） treated group.Liver marker enzymes serum glutamate oxyloacetic transaminase,serum glutamic pyruvic transaminase,pancreatic enzymatic antioxidants superoxide dismutase（SOD）,lipid peroxidation,catalase（CAT）,reduced glutathione（CSH） were measured and compared along with histopathological studies.Results: Obtained results show that the treatment with SCI.E significantly（P<0.05-<0.001） and dosedependently reduced CCl4 induced elevated serum level of hepatic enzymes.Furthermore, SCLE significantly（up to P<0.001） reduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes CSH,SOD and CAT towards normal levels,which was confirmed by the histopathological studies.Conclusions:The results of this study strongly indicate the protective effect of SCLE against CCl4 induced acute liver toxicity in rats and thereby scientifically support its traditional use.