592 and -1082 interleukin-10 polymorphisms in pulmonary tuberculosis with type 2 diabetes

• Published in: Asian Pacific journal of tropical medicine 2013-07, Vol.6 (7), p.505-509
• Main Author: Guadalupe García-Elorriaga Leila Vera-Ramírez Guillermo del Rey-Pineda Csar Gonzlez-Bonilla
• Format: Article
• Language: English
• Subjects: Adult; Cytokines; Diabetes Mellitus, Type 2 - genetics; Female; Gene Frequency; Genotype; Humans; IL-10; Interleukin-10 - genetics; Male; Mexican Americans - genetics; Middle Aged; Mycobacterium; Polymorphism; Polymorphism, Single Nucleotide - genetics; Pulmonary; Pulmonary tuberculosis; Real-Time Polymerase Chain Reaction; tuberculosis; Tuberculosis, Pulmonary - genetics
• ISSN: 1995-7645; 2352-4146
• DOI: 10.1016/S1995-7645(13)60086-3

<正>Objective:To determine the polymorphisms of Interleukin-10(IL-10)(-592,-1082) in pulmonary tuberculosis(PTB)with and without type 2 diabetes(T2D).Methods:We studied a Mexican mestizo population of 37 patients with TB in remission(TBr) and 40 with active pulmonary TB (PTB),21 patients with TB + T2D.47 blood donors accepted,and 13 healthy health-care workers with tuberculin skin lest positive.Determination of IL-10 polymorphisms was performed by real-lime Polymerase chain reaction.Results:IL-10-592C/A presented in a greater proportion in healthy individuals than in patients with type 2 diabetes and TB in a not quite significant statistically manner.IL-10-1082A/A presented more frequently in the group of patients with both diseases,not being statistically significant in comparison with the group of healthy subjects. Conclusions:This study describes two important new findings.First,it reveals that the IL-10 (-592 A/A and -592 C/C) polymorphisms were found in a greater proportion in a group of patients with T2D and TB than in healthy subjects.Second,the study provides evidence that the(-1082 G/G) polymorphism presented with greater frequency in healthy individuals than in patients with both ol these diseases.