Effect of Chinese herbal compound on liver fibrosis in rabbits with schistosomiasis by B-ultrasound

• Published in: Asian Pacific journal of tropical medicine 2013-08, Vol.6 (8), p.658-662
• Main Authors: Liang, Xiao-Lu, Yuan, Jia-Ying
• Format: Article
• Language: English
• Subjects: Angelica; Angelica sinensis - chemistry; Animals; Anthelmintics - isolation & purification; Anthelmintics - therapeutic use; B-ultrasound; Chinese; Chinese herbal compound; compound; Disease Models, Animal; fibrosis; herbal; Herbal Medicine; Liver; Liver - diagnostic imaging; Liver - pathology; Liver Cirrhosis - pathology; Liver Cirrhosis - prevention & control; Liver fibrosis; Male; Praziquantel; Praziquantel - therapeutic use; Rabbits; Salvia miltiorrhiza; Salvia miltiorrhiza - chemistry; Schistosoma; Schistosomiasis; Schistosomiasis - complications; Schistosomiasis - drug therapy; Treatment Outcome; Ultrasonography
• ISSN: 1995-7645; 2352-4146
• DOI: 10.1016/S1995-7645(13)60114-5

Objective: To explore the value of B-ultrasound on the evaluation of the effects of traditional Chinese medicine compound of Radix astragali , Salvia miltiorrhiza and Angelica sinensis , and TCM + praziquantel on liver fibrosis in rabbits with schistosomiasis. Methods: The hepatic fibrosis model in rabbits with schistosomiasis was established. The experimental animals (24 rabbits) were randomly divided into four groups (group A, B, C and D, n =6). Group A (control group) was only treated by praziquantel; Group B was treated by mixture of Radix astragali and Salvia miltiorrhiza + praziquantel; Group C was treated by mixture of Radix astragali and Angelica sinensis + praziquantel; Group D was treated by mixture of Radix astragali, Salvia miltiorrhiza and Angelica sinensis + praziquantel. Then B-ultrasonogram was used to evaluate the effects. Results: Each group showed certain curative effect on liver fibrosis in rabbits with schistosomiasis. The efficacy of group B, C and D was better than group A, and that of group D was the best. The differences in long diameter, thickness diameter, transverse diameter and portal vein inner diameter of liver before and after treatment were statistically significant ( P <0.05). The liver function indexes and liver fibrosis indexes were significantly improved after treatment ( P <0.05). Conclusions: The mixture of Radix astragali, Salvia miltiorrhiza and Angelica sinensis combined with Western medicine treatment can obviously improve the efficacy on liver fibrosis of schistosomiasis.