Peripheral blood cell variations in cirrhotic portal hypertension patients with hypersplenism

Objective: To explore peripheral blood cell variations in hepatic cirrhosis portal hypertension patients with hypersplenism. Methods: Clinical data of 322 hypersplenism patients with decreased peripheral blood cells, admitted with cirrhotic portal hypertension, was retrospectively studied over the l...

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Published in:Asian Pacific journal of tropical medicine 2013-08, Vol.6 (8), p.663-666
Main Authors: Lu, Yun-Fu, Li, Xin-Qiu, Han, Xiao-Yu, Gong, Xiao-Guang, Chang, Shun-Wu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
blood
Blood Cell Count
cell
Changes
Child
Child, Preschool
cirrhosis
Female
Hepatic
Hepatic cirrhosis portal hypertension
Humans
Hypersplenism - pathology
Hypersplenism - surgery
hypertension
Hypertension, Portal - complications
Hypertension, Portal - pathology
Liver Cirrhosis - complications
Liver Cirrhosis - pathology
Male
Middle Aged
Peripheral
Peripheral blood cell
portal
Retrospective Studies
Splenectomy
Young Adult
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Summary:Objective: To explore peripheral blood cell variations in hepatic cirrhosis portal hypertension patients with hypersplenism. Methods: Clinical data of 322 hypersplenism patients with decreased peripheral blood cells, admitted with cirrhotic portal hypertension, was retrospectively studied over the last 17 years. Results: In 64% (206/322) of patients, more than 2 kinds of blood cell were decreased, including 89 cases of pancytopenia (43.2%), 52 cases of WBC + PLT decrease (25.2%), 29 cases of RBC + PLT decrease (14.1%), and 36 cases of WBC + RBC decrease (17.5%); in 36% (116/322) of patients, single type blood cell decrease occurred, including 31 cases of PLT decrease (26.7%), 29 cases of WBC decrease (25%) and 56 cases of RBC decrease (48.3%). Of 227 routine bone marrow examinations, bone marrow hyperplasia was observed in 118 cases (52.0%), the remainder showed no hyperplasia. For the distinct scope and extent of peripheralblood cell decreases, preoperative blood component transfusions were carried out, then treated by surgery, after whole group splenectomy, the peripheral blood cell count was significantly higher ( P <0.05). Conclusions: Of portal hypertensive patients with splenomegaly and hypersplenism, 64% have simultaneous decrease in various blood cells, 36% have decrease in single type blood cells, 52% of patients have bone marrow hyperplasia. A splenectomy can significantly increase the reduction of peripheral blood cells.
ISSN:1995-7645
2352-4146
DOI:10.1016/S1995-7645(13)60115-7