An experimental study of preventing and treating acute radioactive enteritis with human umbilical cord mesenchymal stem cells

Objective:To test the curative effect of human umbilical cord-derived mesenchymal stem cells on rat acute radioactive enteritis and thus in provide clinical therapeutic basis for radiation sickness.Methods:Human umbilical cord-derived mesenchymal stem cells were cultivated in vitro and the model of...

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Bibliographic Details
Published in:Asian Pacific journal of tropical medicine 2013-12, Vol.6 (12), p.968-971
Main Authors: Wang, Rui, Yuan, Wei, Zhao, Qiang, Song, Peng, Yue, Ji, Lin, Shi-De, Zhao, Ting-Bao
Format: Article
Language:English
Subjects:
Acute
Acute radioactive enteritis
Animals
Cell- and Tissue-Based Therapy
cells
Cells, Cultured
contamination
cord
Disease Models, Animal
enteritis
Enteritis - etiology
Enteritis - prevention & control
Enteritis - therapy
Human
Human umbilical cord mesenchymal stem cells
Humans
Male
mesenchymal
Mesenchymal Stem Cell Transplantation
Radiation Injuries, Experimental - prevention & control
Radiation Injuries, Experimental - therapy
Radioactive
Radioactive contamination
Rat
Rats
Rats, Wistar
stem
umbilical
Umbilical Cord - cytology
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Summary:Objective:To test the curative effect of human umbilical cord-derived mesenchymal stem cells on rat acute radioactive enteritis and thus in provide clinical therapeutic basis for radiation sickness.Methods:Human umbilical cord-derived mesenchymal stem cells were cultivated in vitro and the model of acute radioactive enteritis of rats was established.Then,the umbilical cord mesenchymal stem cells were injected into the rats via tail vein.Visual and histopathiological changes of the experimental rats were observed.Results:After the injection,the rats in the prevention group and treatment group had remarkably better survival status than those in the control group.The histological observations revealed that the former also had better intestinal mucosa structure,more regenerative cells and stronger proliferation activity than the latter.Conclusions:Human umbilical cord-derived mesenchymal stem cells have a definite therapeutic effect on acute radioactive enteritis in rats.
ISSN:1995-7645
2352-4146
DOI:10.1016/S1995-7645(13)60173-X