Diagnosis and multi-modality treatment of adult pulmonary plastoma: Analysis of 18 cases and review of literature

• Published in: Asian Pacific journal of tropical medicine 2014-02, Vol.7 (2), p.164-168
• Main Authors: Wang, Yun-Xi, Zhang, Jing, Chu, Xiang-Yang, Liu, Yi, Li, Fang, Wang, Zhan-Bo, Wei, Li-Xin
• Format: Article
• Language: English
• Subjects: Aged; blastoma; Combined Modality Therapy; Diagnosis; Female; Humans; Lung Neoplasms - diagnosis; Lung Neoplasms - pathology; Lung Neoplasms - therapy; Male; Middle Aged; Prognosis; Pulmonary; Pulmonary blastoma; Pulmonary Blastoma - diagnosis; Pulmonary Blastoma - pathology; Pulmonary Blastoma - therapy; Radiography, Thoracic; Retrospective Studies; Treatment
• ISSN: 1995-7645; 2352-4146
• DOI: 10.1016/S1995-7645(14)60015-8

The clinical data of 18 patients with PB from April 1989 to April 2013 was analyzed retrospectively,including 11 men and 7 women,aged 45 and 76 years old(mean 53 years).There were 12 eases of PB occurrlng in right lung and other cases in left lung,AraBng them,3 patients had no symptoms,and 15 patients displayed symptoms of cough,chest pain,asthenia or minor hacmoptysis.Overall,11 patients had a preoperative diagnosis of lung cancer,7 patients were preoperatively diagnosed as the other disease,which included lung benign tumor(n=5)and mediastinal mass(n=2).All patients received a radical resection.Six patients received postoperative cisplalinbascd chemothcrapy,and two paticnts received postoperative irradiation with the dose of 55 Gy.Histologically.14 eases of 18 patients had biphasie pulmonary blastema and four cases had well differentiated fetal adenocarcinoma.A total of 12 patients died in a period of 6-36 months after operation,and 1 ease was lost after 2 years of follow up.The median survival time was 19 months,PB is a rare primary lung malignant embryonal neoplasm.Despite its assumed embyonal origin,the tumor has a predileetion for adults.A preoperative correct diagnosis is very difficult in spite of modern diagnostic imaging and biopsy techniques,Surgical resection is the main method for diagnosis and treatment.Postoperative chemotherapy or irradiation can help eliminate tumor remnants.Its prognosis is very poor,especially for the biphasie type.