Effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-tumor role

Objective:To observe the effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-tumor role.Methods:Human intestinal cancer cell HT29 xenograft of nude mice model was established.The expression of ECF,VEGF,gastric cancer tumor growth in mice were observed.R...

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Published in:Asian Pacific journal of tropical medicine 2014-05, Vol.7 (5), p.378-381
Main Authors: Fu, Li-Ran, Guo, Sheng-Wei, Liu, Xian-Hui
Format: Article
Language:English
Subjects:
Animals
Anti-cancer
Anti-cancer treatment
Antineoplastic Agents - pharmacology
Apoptosis - drug effects
cancer
Colorectal Neoplasms
deficiency
Drugs, Chinese Herbal - pharmacology
HT29 Cells
Humans
Intestinal
Intestinal cancer
Jianpi
Mice
Mice, Nude
Spleen - drug effects
Spleen-qi
Spleen-qi deficiency
treatment
Xenograft Model Antitumor Assays
Yiqi
Yiqi Jianpi
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Summary:Objective:To observe the effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-tumor role.Methods:Human intestinal cancer cell HT29 xenograft of nude mice model was established.The expression of ECF,VEGF,gastric cancer tumor growth in mice were observed.Results:Protein kinase C expression in in the Yiqi Jianpi group and Yiqi Jianpi anti-tumor group was significantly better than the model group(P<0.01,P<0.05).There was significantly more apoptotic cells in Yiqi Jianpi anti-tumor group than Yiqi Jianpi group and model group(P<0.01).Epidermal growth factor and vascular endothelial growth factor expression in Yiqi Jianpi group was significantly lower than Yiqi Jianpi group and model group(P<0.05).Conclusions:Tumor can inhibit the expression of PKC inhibition.Yiqi Jianpi and anticancer treatment can reduce this inhibition.Besides this treatment can also inhibit expression of tumor related genes such as epidermal growth factor and vascular endothelial growth factor.
ISSN:1995-7645
2352-4146
DOI:10.1016/S1995-7645(14)60059-6