Anti-inflammatory and analgesic activities with gastroprotective effect of semi-purified fractions and isolation of pure compounds from Mediterranean gorgonian Eunicella singularis

Objective: To explore anti-inflammatory activities of organic extract and its semi-purified fractions(ethanol, acetone, methanol/dichloromethane) from the Mediterranean gorgonian Eunicella singularis. Methods: The anti-inflammatory and analgesic activities were evaluated, using the carrageenan-induc...

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Bibliographic Details
Published in:Asian Pacific journal of tropical medicine 2015-08, Vol.8 (8), p.598-603
Main Authors: Deghrigue, Monia, Festa, Carmen, Ghribi, Lotfi, D'Auria, Maria Valeria, De Marino, Simona, Ben Jannet, Hichem, Bouraoui, Abderrahman
Format: Article
Language:English
Subjects:
activity
Analgesic
Analgesic activity
Anti-inflammatory
Anti-inflammatory activity
Diterpenoid
effect
Eunicella
Eunicella singularis
Gastroprotective
Gastroprotective effect
singularis
Sterols
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Summary:Objective: To explore anti-inflammatory activities of organic extract and its semi-purified fractions(ethanol, acetone, methanol/dichloromethane) from the Mediterranean gorgonian Eunicella singularis. Methods: The anti-inflammatory and analgesic activities were evaluated, using the carrageenan-induced rat paw edema model and the acetic acid writhing test in mice. The gastroprotective activity was determined using HCl/Et OH induced gastric ulcers in rats. The purification and structure elucidation of compound(s) from the more effective fraction were determined by chromatographic and spectroscopic methods and in comparison with data reported in the literature. Results: The fraction F-Et OH showed an important antiinflammatory activity associated with significant analgesic and gastroprotective properties. The purification and structure elucidation of compound(s) from this fraction lead to the identification of one diterpenoid and four sterols. Conclusions: These results suggested that components from the active fraction can be used to treat various anti-inflammatory diseases.
ISSN:1995-7645
2352-4146
DOI:10.1016/j.apjtm.2015.07.019