Moving boundary problem for diffusion release of drug from a cylinder polymeric matrix

An approximate analytical solution of moving boundary problem for diffusion release of drug from a cylinder polymeric matrix was obtained by use of refined integral method. The release kinetics has been analyzed for non-erodible matrices with perfect sink condition. The formulas of the moving bounda...

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Bibliographic Details
Published in:Applied mathematics and mechanics 2001-04, Vol.22 (4), p.379-384
Main Authors: Tan, W C, Wu, W Y, Yan, Z Y, Wen, G B
Format: Article
Language:English
Subjects:
Boundary conditions
Diffusion
Drug therapy
Mathematical models
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Summary:An approximate analytical solution of moving boundary problem for diffusion release of drug from a cylinder polymeric matrix was obtained by use of refined integral method. The release kinetics has been analyzed for non-erodible matrices with perfect sink condition. The formulas of the moving boundary and the fractional drug release were given. The moving boundary and the fractional drug release have been calculated at various drug loading levels, and the calculated results were in good agreement with those of experiments. The comparison of the moving boundary in spherical, cylinder, planar matrices has been completed. An approximate formula for estimating the available release time was presented. These results are useful for the clinic experiments. This investigation provides a new theoretical tool for studying the diffusion release of drug from a cylinder polymeric matrix and designing the controlled released drug.
ISSN:0253-4827
1573-2754
DOI:10.1007/BF02438303