Capillary electrophoresis with direct chemiluminescence detection for the analysis of catecholamines in human urine

A rapid and sensitive method for the analysis of three catecholamines by capillary electrophoresis (CE) with direct chemiluminescence (CL) detection is described. The detection limits (S/N = 3) were 1.3 × 10 −8 g/mL for isoprenaline, 1.0 × 10 −8 g/mL for epinephrine and 2.8 × 10 −8 g/mL for dopamine...

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Bibliographic Details
Published in:Chinese chemical letters 2007-04, Vol.18 (4), p.452-454
Main Authors: Wang, Cheng Quan, Wang, Hui, Liu, Yan Ming
Format: Article
Language:English
Subjects:
Capillary electrophoresis
Catecholamines
Chemiluminescence detection
Urine
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Summary:A rapid and sensitive method for the analysis of three catecholamines by capillary electrophoresis (CE) with direct chemiluminescence (CL) detection is described. The detection limits (S/N = 3) were 1.3 × 10 −8 g/mL for isoprenaline, 1.0 × 10 −8 g/mL for epinephrine and 2.8 × 10 −8 g/mL for dopamine. The proposed method was successfully applied to the analysis of catecholamines in urine samples of cigarette smokers and nonsmokers. The results showed that there is a close relation between the release of dopamine in human body fluids and cigarette smoking/nonsmoking.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2007.02.009