Antioxidant activity of bovine serum albumin binding amino acid Schiff-bases metal complexes

Glutamic acid–salicylaldehyde Schiff-base metal complexes are bound into bovine serum albumin (BSA), which afforded BSA binding Schiff-base metal complexes (BSA-SalGluM, M Cu, Co, Ni, Zn). The BSA binding metal complexes were characterized by UV–vis spectra and Native PAGE. It showed that the protei...

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Bibliographic Details
Published in:Chinese chemical letters 2007-11, Vol.18 (11), p.1416-1418
Main Authors: Wang, Rong Min, Mao, Juan Juan, Song, Jing Feng, Huo, Cai Xia, He, Yu Feng
Format: Article
Language:English
Subjects:
Antioxidants
Bovine serum albumin (BSA)
Glutamic acid
Hydroxyl radicals
Natural polymer
Schiff-base metal complexes
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Summary:Glutamic acid–salicylaldehyde Schiff-base metal complexes are bound into bovine serum albumin (BSA), which afforded BSA binding Schiff-base metal complexes (BSA-SalGluM, M Cu, Co, Ni, Zn). The BSA binding metal complexes were characterized by UV–vis spectra and Native PAGE. It showed that the protein structures of BSA kept after coordinating amino acid Schiff-bases metal complexes. The effect of the antioxidant activity was investigated. The results indicate that the antioxidant capacity of BSA increased more than 10 times after binding Schiff-base metal complexes.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2007.09.015