A novel synthesis of pyrazolo[3,4- b]pyridine derivatives through multi-component reaction in ionic liquid

An efficient and novel procedure for the preparation of pyrazolo[3,4- b]pyridine derivatives through multi-component reaction of aldehyde, 5-amino-3-methyl-1-phenylpyrazole and malononitrile or cyanoacetate in [bmim][BF 4] is described in this paper. Advantages of the method presented here include m...

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Bibliographic Details
Published in:Chinese chemical letters 2008-02, Vol.19 (2), p.153-156
Main Authors: Zhang, Xin Ying, Li, Xiao Yan, Fan, Xue Sen, Wang, Xia, Wang, Jian Ji, Qu, Gui Rong
Format: Article
Language:English
Subjects:
Ionic liquid
Multi-component reaction
Pyrazolo[3,4- b]pyridine
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Summary:An efficient and novel procedure for the preparation of pyrazolo[3,4- b]pyridine derivatives through multi-component reaction of aldehyde, 5-amino-3-methyl-1-phenylpyrazole and malononitrile or cyanoacetate in [bmim][BF 4] is described in this paper. Advantages of the method presented here include mild conditions, high yields together with a green nature and ease of recovery and reuse of the reaction medium.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2007.12.009