Evaluation of lipid peroxidation inhibition and free radical scavenging abilities of 5,6,7-tfimethoxy dihydroflavonols

O6; Four naturally rare 5,6,7-trimethoxy-2,3-cis-dihydroflavonols (3-6) and two 5,6,7-trimethoxy-2,3-trans-dihydroflavonols (7-8) were designed and synthesized. Their antioxidative properties were evaluated by way of examining their scavenging capacities towards DPPH and O_2~(·-) free radicals,as we...

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Published in:中国化学快报（英文版） 2009, Vol.20 (10), p.1187-1190
Main Authors: Ke Xin Huang, Yu Bing Feng, Wei Yao, Lei Xiang Yang, Feng Wang, Hai Bo Li, Su Zeng, Jing Xu Gong, Ming Hui Hu, Yu Zhao, Xiu Mei Wu, Xiao Kun Li, Jia Qu
Format: Article
Language:English
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Summary:O6; Four naturally rare 5,6,7-trimethoxy-2,3-cis-dihydroflavonols (3-6) and two 5,6,7-trimethoxy-2,3-trans-dihydroflavonols (7-8) were designed and synthesized. Their antioxidative properties were evaluated by way of examining their scavenging capacities towards DPPH and O_2~(·-) free radicals,as well as by measuring their inhibitory ability against LPO.Both the 2,3-trans and the 2,3-cis conformers exhibited certain quenching abilities to DPPH and O_2~(·-) radicals,while most of the synthetic dihydroflavonols demonstrated remarkable inhibition to LPO.
ISSN:1001-8417
DOI:10.1016/j.cclet.2009.04.026