Synthesis and cytotoxicity of novel podophyllotoxin derivatives

In order to find novel synthetic antitumor agents with superior cytotoxicity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents. Seven novel podophyllotoxin derivatives were synthesized by l...

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Bibliographic Details
Published in:Chinese chemical letters 2009-12, Vol.20 (12), p.1431-1434
Main Authors: Zheng, Yi, Sun, You Guang, Zhang, Yuan, Lv, Jing Jing, Bi, Wen Chao, Ma, Yuan Wei, Chen, Hong
Format: Article
Language:English
Subjects:
Antitumor
Chemosynthesis
K562
Multidrug resistance
Podophyllotoxin derivatives
体外试验
多药耐药
抗肿瘤药物
细胞毒性
还原方法
鬼臼毒素衍生物
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Summary:In order to find novel synthetic antitumor agents with superior cytotoxicity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents. Seven novel podophyllotoxin derivatives were synthesized by linking 4β-amino-4-deoxypodophyllotoxin with N-substituted 5-methylindol-3- yl-glyoxyl chlorides and tested against K562 and K562/A02 using SRB methods in vitro, KB and KBVusing MTT methods in vitro.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2009.07.022