A mild and efficient method for nucleophilic aromatic fluorination using tetrabutylammonium fluoride as fluorinating reagent

Anhydrous tetrabutylammonium fluoride(TBAF_(anh).) has been found to be a highly efficient fluorinating reagent for nucleophilic aromatic fluorinations such as fluorodenitration or halogen exchange(Halex) reaction.The products were formed in high to excellent yields under surprisingly mild reaction...

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Bibliographic Details
Published in:Chinese chemical letters 2010-02, Vol.21 (2), p.151-154
Main Authors: Hu, Yu Feng, Luo, Jun, Lü, Chun Xu
Format: Article
Language:English
Subjects:
Fluoroaromatics
Fluorodenitration
Halex
TBAF anh
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Summary:Anhydrous tetrabutylammonium fluoride(TBAF_(anh).) has been found to be a highly efficient fluorinating reagent for nucleophilic aromatic fluorinations such as fluorodenitration or halogen exchange(Halex) reaction.The products were formed in high to excellent yields under surprisingly mild reaction conditions and no phenol or ether side-products were detected in these reactions.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2009.10.014