The heavy atom effect on photocleavage of DNA by mono-hydroxyl halogenated corroles

DNA photocleavage properties of halogenated mono-hydroxyl corrole 1-5 were investigated.It was found that these corroles were able to photocleavage supercoiled pBR 322 DNA(SC) into nicked-circular DNA(NC).The activity of these corroles follows an order of 4>3>2≈1>5.The photosensitized singl...

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Bibliographic Details
Published in:Chinese chemical letters 2010-03, Vol.21 (3), p.373-375
Main Authors: Shi, Lei, Liu, Hai Yang, Si, Li Ping, Peng, Kai Mei, You, Li Li, Wang, Hui, Zhang, Lei, Ji, Liang Nian, Chang, Chi Kwong, Jiang, Huan Feng
Format: Article
Language:English
Subjects:
Corrole
DNA
Heavy atom effect
Photocleavage
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Summary:DNA photocleavage properties of halogenated mono-hydroxyl corrole 1-5 were investigated.It was found that these corroles were able to photocleavage supercoiled pBR 322 DNA(SC) into nicked-circular DNA(NC).The activity of these corroles follows an order of 4>3>2≈1>5.The photosensitized singlet oxygen(Φ_△) quantum yield by these corroles also follows that same order,showing the photocleavage activity is related to the heavy atom effect of halogen atoms on corroles.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2009.11.027